Ectonucleotidase Inhibitory and Redox Activity of Imidazole-Based Organic Salts and Ionic Liquids
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BOLDESCU, Veaceslav, SUCMAN, Natalia, HASSAN, Sidra, IQBAL, Jamshed, NEAMŢU, Mariana, LECKA , Joanna, SEVIGNY, Jean, PRODIUS, Denis, MAKAEV, Fliur. Ectonucleotidase Inhibitory and Redox Activity of Imidazole-Based Organic Salts and Ionic Liquids. In: ChemMedChem, 2018, nr. 13(21), pp. 2297-2304. ISSN 1860-7179. DOI: https://doi.org/10.1002/cmdc.201800520
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ChemMedChem
Numărul 13(21) / 2018 / ISSN 1860-7179

Ectonucleotidase Inhibitory and Redox Activity of Imidazole-Based Organic Salts and Ionic Liquids

DOI: https://doi.org/10.1002/cmdc.201800520

Pag. 2297-2304

Boldescu Veaceslav1, Sucman Natalia1, Hassan Sidra2, Iqbal Jamshed2, Neamţu Mariana3, Lecka Joanna4, Sevigny Jean4, Prodius Denis15, Makaev Fliur1
 
1 Institute of Chemistry of the Academy of Sciences of Moldova,
2 COMSATS Institute of Information Technology,
3 Alexandru Ioan Cuza University of Iaşi,
4 Université Laval, Québec,
5 Ames Laboratory, US Department of Energy and Critical Materials Institute, Ames, IA
 
Disponibil în IBN: 3 decembrie 2018


Rezumat

Cytotoxicity against cancer and normal cells, inhibition of ectonucleotidase, and redox properties of a new group of imidazole-based organic salts and ionic liquids were studied. The tetrachloroferrate salt of a 1-methylimidazole derivative of salicylic aldehyde had most prominent inhibitory activity against ectonucleotidase as well as a higher cytotoxicity against HeLa cells and lower cytotoxicity against BHK-21 cells than the reference compound carboplatin. The studied compounds exhibited a moderate level of antioxidant activity with better results for the salicylic aldehyde derivatives than for spiropyrans. Moreover, these compounds did not generate singlet oxygen.

Cuvinte-cheie
antioxidants, cancer, ectonucleotidase, ionic liquids, organic salts

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