Ectonucleotidase Inhibitory and Redox Activity of Imidazole-Based Organic Salts and Ionic Liquids
Închide
Conţinutul numărului revistei
Articolul precedent
Articolul urmator
88 0
SM ISO690:2012
BOLDESCU, Veaceslav; SUCMAN, Natalia; HASSAN, Sidra; IQBAL, Jamshed; NEAMŢU, Mariana; LECKA , Joanna; SEVIGNY, Jean; PRODIUS, Denis; MACAEV, Fliur. Ectonucleotidase Inhibitory and Redox Activity of Imidazole-Based Organic Salts and Ionic Liquids. In: ChemMedChem. 2018, nr. 13(21), pp. 2297-2304. ISSN 1860-7179.
EXPORT metadate:
Google Scholar
Crossref
CERIF
BibTeX
DataCite
Dublin Core
ChemMedChem
Numărul 13(21) / 2018 / ISSN 1860-7179

Ectonucleotidase Inhibitory and Redox Activity of Imidazole-Based Organic Salts and Ionic Liquids


DOI: 10.1002/cmdc.201800520
Pag. 2297-2304

Boldescu Veaceslav1, Sucman Natalia1, Hassan Sidra2, Iqbal Jamshed2, Neamţu Mariana3, Lecka Joanna4, Sevigny Jean4, Prodius Denis15, Macaev Fliur1
 
1 Institute of Chemistry of the Academy of Sciences of Moldova,
2 COMSATS Institute of Information Technology,
3 „Alexandru Ioan Cuza” University, Iasi,
4 Université Laval, Québec,
5 Ames Laboratory, US Department of Energy and Critical Materials Institute, Ames, IA
 
Disponibil în IBN: 3 decembrie 2018


Rezumat

Cytotoxicity against cancer and normal cells, inhibition of ectonucleotidase, and redox properties of a new group of imidazole-based organic salts and ionic liquids were studied. The tetrachloroferrate salt of a 1-methylimidazole derivative of salicylic aldehyde had most prominent inhibitory activity against ectonucleotidase as well as a higher cytotoxicity against HeLa cells and lower cytotoxicity against BHK-21 cells than the reference compound carboplatin. The studied compounds exhibited a moderate level of antioxidant activity with better results for the salicylic aldehyde derivatives than for spiropyrans. Moreover, these compounds did not generate singlet oxygen.

Cuvinte-cheie
antioxidants, cancer, ectonucleotidase, ionic liquids, organic salts