|Conţinutul numărului revistei|
| SM ISO690:2012|
BOLDESCU, Veaceslav; SUCMAN, Natalia; HASSAN, Sidra; IQBAL, Jamshed; NEAMŢU, Mariana; LECKA , Joanna; SEVIGNY, Jean; PRODIUS, Denis; MACAEV, Fliur. Ectonucleotidase Inhibitory and Redox Activity of Imidazole-Based Organic Salts and Ionic Liquids. In: ChemMedChem. 2018, nr. 13(21), pp. 2297-2304. ISSN 1860-7179.
|Numărul 13(21) / 2018 / ISSN 1860-7179|
Cytotoxicity against cancer and normal cells, inhibition of ectonucleotidase, and redox properties of a new group of imidazole-based organic salts and ionic liquids were studied. The tetrachloroferrate salt of a 1-methylimidazole derivative of salicylic aldehyde had most prominent inhibitory activity against ectonucleotidase as well as a higher cytotoxicity against HeLa cells and lower cytotoxicity against BHK-21 cells than the reference compound carboplatin. The studied compounds exhibited a moderate level of antioxidant activity with better results for the salicylic aldehyde derivatives than for spiropyrans. Moreover, these compounds did not generate singlet oxygen.
antioxidants, cancer, ectonucleotidase, ionic liquids, organic salts