One of the basic reserves of productive potential to agricultural animals is the prevention of parasitic disease. The parasitosis were and remain to be a major problem in the field of domestic animal husbandry, due to economic losses which are recorded in the respective field. At the same time, some zoonoses creates serious social problems, because has the risk of spread and transmission to humans (Screabin K., 1963, Olteanu Gh. et al., 1999, Safiulin R., 2005). The analysis of the scientific literature in this problem, shows that the parasites in animals are widely distributed (in some cases of 100%) and bring great economic harm to zootechnic sector. It is obvious that the host organism is in a permanent monoparasites relation with population of each species, in the same time with that poliparasitar existing in respective organism. The poliparasitar invasions, actually, are meet at domestic and wild animals, and to humans (Spaskii A. et.al., 1963, Suteu I., 1996, Zgardan E., Erhan D., Rusu St. et al., 2008). Although the economic situation from the last years in households from the Republic of Moldova is difficult, the domestic animal husbandry remains an important branch of perspective of the zootechnics. Because the treating of parasitic diseases requires the use of specific remedies, knowing of their action mechanism on the hostbody has a principled significance. The immunological changes that occur in the body to infestations with parasitic agents and to administration of chemo-therapeutic remedies, are not studied enough. The negative secondary effect of chemo-therapy is directly determined by the action of the medicine on imunogenesis and of massive penetration of somatic or metabolic antigens of the parasite in the body after treatment. Some medicines inhibits the imunogenesis of body and acts negatively on the development of basic disease (Ozeretkovskaia N., 1987, Daugalieva A., Kolenikov V., Novitkii S., 1997, Olteanu Gh. et.al., 2001, Erhan D., 2010, Nicolae C. et.al., 2014). The prophylaxis and treatment of parasitosis demonstrate that administration of chemical-pharmaceutical remedies, especially of anthelmintic, are aimed at damaging and removing of the parasites from the body. The fight with parasites, usually, takes place without the evidence of protection mechanisms of the body in which they grow  (Suteu I., 1996, Suteu I., Cozma V., 2007, Iakubovskii М., 2008). Having a broad therapeutic spectrum extending on insects, arachnoids, nematodes and low-dose administration, the Ivermectiged 1% medicine, produced by Euro Prime Pharmaceuticals LLC, Republic of Moldova, inoculated at bovines in dose of 1 ml/50 kg b.m., swine - 1ml / 33 kg b.m. and to the sheep in dose of 0.5 ml / 25 kg b.m., make part of macrocyclic lactones, medicines which have taken a real spread in antiparasitic therapy in animals in many of the world tart (Suteu I; 1995). To the sheep, the ivermectin is indicated in the treatment and prophylaxis of pulmonary and gastrointestinal nematodes, of the itch and estrosis (Olteanu Gh. et al., 2001). The avermectins are well tolerated by animals, but small deviations in overcoming of therapeutic dosage does not cause acute poisoning (Darabus Gh. et al., 2003). The aim of the present paper is to assess the action of Ivermectiged product (Euro Prime Pharmaceuticals LLC) containing 1% of ivermectin for the treatment of ecto- and endo- parazitosis, that can be found at sheep in the Republic of Moldova. The tests were carried out on sheeps at a private property, located in the village of Gradiste, Cimişlia district. The consignments of animals were distributed as follows: experimental group of 20 animals (10 adult sheep and 10 young sheep), and the control group - 6 animals (3 adults sheep and 3 young sheep). From the experimental group 35% of sheep, at ante-therapeutic clinical examination, presented crust dermatitis lesions. From the material obtained by scraping, after microscopic examination, were found mites from Psoroptes ovis species. The animals have undergone the treatment in accordance with the instruction of administration, inoculate to them 0,5 ml/25 kg b.m. At the recontrol performed at the 14th day of post-treatment was found missing of crusts, absence of psoric reflex, and microscopic examination hasn’t revealed evolutionary forms of Psoroptes ovis. The ivermectiged administered subcutaneously in a dose of 0.5 ml / 25 kg of body weight has an effectiveness of 97-99% in 7-20 days. Having a broad antiparasitis spectrum, the medicine has the advantage of being administered in any season. This effect is confirmed by Suteu I. and Dulceanu N. (2001) in respect of other avermectin. The coproparasitologic exam, conducted pre-therapeutic on animals from this experiment, revealed infestations associated with parasites from Dicrocoelium, Eimeria, Strongyloides genres (pulmonary and digestive), who presented consecutively following percentage indices: 95%; 30%; 60%. The control group showed a similar level of infestation. After 14 days the coproparasitologic exam revealed the maintenance of infestation with Dicrocoelium lanceolatum, of the infection with Eimeria and lack of infestations with lung and digestive strongyls. To the control group have been showed the same values found in ante-therapeutic control. In the result of research on the therapeutic efficacy of the Ivermectiged 1% product to the sheep, we conclude the following: Dicrocoelium lanceolatum and Eimeria ssp. were found at ante-therapeutic and at the post-therapy controls, which suggests that the ivermectin does not act in these parasitosis. The ivermectiged of 1% has maximum efficacy in the treatment of lung and digestive strongylidosis. It was also found an efficacy of 97-99% in the treatment of psoroptic scabies at sheep.