Sinteza unor derivați ai 1,2,4-triazolului &icirc;n baza n-[4-(3-metil-5-sulfanil-4h-1,2,4-triazol-4-il)fenil]acetamidei

Rusnac Roman; Garbuz Olga; Barbă Nicanor; Gulea Aurelian; Balan Greta; Bruduniuc Olga

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Articolul precedent

Articolul urmator

794

Ultima descărcare din IBN:
2024-04-12 10:51

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similare conform CZU

547.792.2 (1)

Chimie organică (484)

SM ISO690:2012

RUSNAC, Roman, GARBUZ, Olga, BARBĂ, Nicanor, GULEA, Aurelian, BALAN, Greta, BRUDUNIUC, Olga. Sinteza unor derivați ai 1,2,4-triazolului în baza n-[4-(3-metil-5-sulfanil-4h-1,2,4-triazol-4-il)fenil]acetamidei. In: Studia Universitatis Moldaviae (Seria Ştiinţe Reale şi ale Naturii), 2018, nr. 1(111), pp. 133-143. ISSN 1814-3237.

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Studia Universitatis Moldaviae (Seria Ştiinţe Reale şi ale Naturii)

Numărul 1(111) / 2018 / ISSN 1814-3237 /ISSNe 1857-498X

Sinteza unor derivați ai 1,2,4-triazolului în baza n-[4-(3-metil-5-sulfanil-4h-1,2,4-triazol-4-il)fenil]acetamidei

Ynthesis of derivatives of 1,2,4-triazol based on n-[4-(3-methyl-5-sulfanyl-4h-1,2,4-triazol-4-yl)phenyl]acetamide

CZU: 547.792.2

Pag. 133-143

Rusnac Roman¹, Garbuz Olga¹, Barbă Nicanor¹, Gulea Aurelian¹, Balan Greta², Bruduniuc Olga³

¹ Universitatea de Stat din Moldova,
² Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“,
³ Agenţia Naţională pentru Sănătate Publică

Disponibil în IBN: 30 septembrie 2018

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În articol sunt descrise metodele de sinteză a 8 compuși organici din seria 1,2,4-triazol-3-tiolilor, dintre care 7 compuși sunt noi, a căror structură a fost confirmată prin sinteză și cu ajutorul metodelor spectrale: ¹H-RMN, ¹³C-RMN și IR (FTIR). Compușii (2) și (3) au fost investigați cu ajutorul difracției razelor X pe monocristal. Unii compuși obținuți au demonstrat proprietăți antiproliferative moderate: inhibă creșterea celulelor de HEp-2 și BxPC-3. Activitate antifungică au demonstrat compușii (2) și (7), cu o valoare a CMI de 0,125 μg/mL. Proprietățile antioxidative au fost studiate cu ajutorul metodei ABTS și DPPH; astfel, cel mai bun atioxidant s-a dovedit a fi 2-[(2- hidroxifenil)metiliden]-N-[4-(3-metil-5-sulfanil-4H-1,2,4-triazol-4-il)fenil]hidrazin-1-carbotioamida (7)..

The article describes the synthesis methods of 8 organic compounds from the 1,2,4-triazole-3-thiol series, of which 7 compounds are new. The structure of compounds was confirmed by spectral methods: ¹H-NMR, ¹³C -RMN and IR (FTIR). The triazoles (2) and (3) were investigated by X-ray diffraction on monocrystal. Some compounds have demonstrated moderate antiproliferative properties, in growth of HEp-2 and BxPC-3 cells. Antifungal activity is characteristic far compounds (2) and (7) with a MIC of 0.125 μg/mL. Antioxidative properties were studied using the ABTS and DPPH method where the best one was found to be 2-[(2-hydroxyphenyl)methylidene]-N-[4-(3-methyl-5- sulfanyl-4-triazol-4-yl)phenyl]hydrazine-1-carbothioamide (7).

Cuvinte-cheie
1, 2, anticancer,

4-triazol, tiosemicarbazone,

antioxidativ, N-fenil-acetamidă.

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