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Ultima descărcare din IBN: 2024-04-01 13:37 |
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616-053.2:612.013 (1) |
Patologie. Medicină clinică (6963) |
Fiziologie. Fiziologie umană și comparată (725) |
SM ISO690:2012 COJOCARI, Svetlana, MĂTRĂGUNĂ, Nelea, BICHIR-THOREAC, Liliana. Factorii de risc ai sindromului metabolic la copii: rolul obezităţii. In: Buletin de Perinatologie, 2018, nr. 4(80), pp. 3-13. ISSN 1810-5289. |
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Buletin de Perinatologie | ||||||
Numărul 4(80) / 2018 / ISSN 1810-5289 | ||||||
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CZU: 616-053.2:612.013 | ||||||
Pag. 3-13 | ||||||
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Rezumat | ||||||
Background. Although the metabolic syndrome (MS) has been the subject of the numerous researches at adults for years, when speaking about children MS has not been studied well and still there are controversial points of view. This fact reveals the necessity of the investigations in the domain. Material and methods. The research included 218 children with overweight/obesity (aged-10-18) divided according to the presence of MS (IDF, 2007) into 2 groups: group I – 46 children with MS and group II – 172 children without MS. Leptin, adiponectin and TNF-α were estimated through the immunoenzymatic method - ELISA, hs-CRP - latex- immunoturbidimetry method, serum insulin - immunochemical method with detection through electrochemiluminescence (ECLIA). Polymorphism of the candidate genes was identified using the method of analysis of the amplified fragments length and polymorph restriction fragments. Results. MS (IDF, 2007) was diagnosed in 21,10% children included in the research. Among the children with MS prevailed carriers of the genotype DD of ACE (70,97%) and CC of AGTR1 A1166C (51,61%). Premature babies in comparison with post mature and full term babies had higher values of BMI (31,6±0,82 vs 28,6±0,47 and 28,8±0,30; p<0,001), AC (99,8±2,60 vs 90,1±2,20 and 89,1±0,87 cm; p<0,001) and of SBP (150,1±5,02 vs 121,7±4,46 and 134,6±2,29 mmHg; p<0,001). Children with MS as compared to children without MS had higher values of insulin (31,26±2,22 vs 16,71±0,65 μU/ml; p<0,001), hs-CRP (3,65±0,142 vs 2,25±0,084 mg/l; p<0,001), TNF-α (13,07±0,683 vs 7,48±0,206 pg/ml; p<0,001), leptin (20,47±0,948 vs 11,74±0,390 ng/ml; p<0,001), but lower of adiponectin (5,18±0,157 vs 6,80±0,134 ng/ml; p<0,001). Proinflammatory markers, hypo-adiponectinemia and hiperleptinemia had a fi rm relation with MS as a whole, as well as with its components. Conclusions. High rate of MS in children with obesity or overweight, stated in the present research enforce the necessity of the obligatory screening of the risk factors for this syndrome at all children with overweight, but biomarkers that integrate metabolic and inflammatory signals can really serve as useful tools for early diagnosis of MS components. |
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Cuvinte-cheie metabolic syndrome, children, risk factors, biomarkers |
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