Schiff bases containing a furoxan moiety as potential nitric oxide donors in plant tissues

Georgescu Emilian I.; Oancea Anca Olguţa; Georgescu Florentina; Nicolescu Alina Florica; Opriţa Elena Iulia; Vladulescu Lucian; Vladulescu Marius Constantin; Oancea Florin; Shova Sergiu; Deleanu Călin

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GEORGESCU, Emilian I., OANCEA, Anca Olguţa, GEORGESCU, Florentina, NICOLESCU, Alina Florica, OPRIŢA, Elena Iulia, VLADULESCU, Lucian, VLADULESCU, Marius Constantin, OANCEA, Florin, SHOVA, Sergiu, DELEANU, Călin. Schiff bases containing a furoxan moiety as potential nitric oxide donors in plant tissues. In: PLoS ONE, 2018, nr. 7(13), p. 0. ISSN 1932-6203. DOI: https://doi.org/10.1371/journal.pone.0198121

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PLoS ONE

Numărul 7(13) / 2018 / ISSN 1932-6203

Schiff bases containing a furoxan moiety as potential nitric oxide donors in plant tissues

DOI:https://doi.org/10.1371/journal.pone.0198121

Pag. 0-0

Georgescu Emilian I.¹, Oancea Anca Olguţa², Georgescu Florentina³, Nicolescu Alina Florica⁴⁵, Opriţa Elena Iulia², Vladulescu Lucian³, Vladulescu Marius Constantin³, Oancea Florin³, Shova Sergiu⁴⁶, Deleanu Călin⁴⁵

¹ Centrul de Cercetare Oltchim, Ramnicu Valcea,
² Institutul National de Cercetare-Dezvoltare pentru Stiinte Biologice,
³ Teso Spec SRL,
⁴ “Petru Poni” Institute of Macromolecular Chemistry,
⁵ "C.D. Nenitzescu" Centre of Organic Chemistry, Romanian Academy,
⁶ Institute of Chemistry of the Academy of Sciences of Moldova

Disponibil în IBN: 8 august 2018

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Stable Schiff bases containing a furoxan moiety are synthesized as single regioisomers by the reaction of 3-methyl-2-oxy-furazan-4-carbaldehydewith various amino compounds at room temperature. The structures of synthesized compounds were fully characterized by multinuclear NMR spectroscopy and X-ray crystallography. The effect of synthesized Schiff bases containing a furoxan moiety on biological generation of reactive oxygen species and nitric oxide in plant tissues was investigated for the first time by fluorescence microscopy and the released NO identified as nitrite with Griess reagent. There is a good correlation between the biological generation of NO determined by fluorescence microscopy and with Griess reagent. Some of the synthesized compounds exhibited both nitric oxide and reactive oxygen species generation abilities and represent potential NO donors in plant tissues.