Introducere. Hiperparatiroidismul primar este la ora actuală un subiect discutat în literatură, se caracterizează prin secreţia exagerată de PTH şi dispariţia fenomenului de feedback dintre producţia PTH şi nivelul seric al calciului, acestea se datorează adenoamelor în 95% cazuri. Scopul lucrării. Evaluarea manifestărilor clinice în HPP, eficienţa informaţională a analizelor hormonale, metode de diagnostic şi tratament. Material şi metode. A fost efectuat un studiu retrospectiv asupra bolnavilor internaţi în secţia chirugie VAE, SCR în perioda 2013-2016, diagnosticaţi cu HPP primar (n=24 de pacienţi). Pacienţii au fost evaluaţi clinic, paraclinic, imagistic şi tactica tratamentului. Rezultate. 24 de cazuri au fost cu HPP primar, 5 bărbaţi (21%) şi 19 femei (79%), cu o vârstă medie 50-70 ani. Manifestările clinice: osteo-articulare (58.8%, n=14), renale (25.2%, n=6), neuro-psihice (8.4%, n=2), digestive (8.4%, n=2). Diagnostic pozitiv: dozarea calcemiei de 12.1±0.47 mg//dL, a fosfatemiei de 500±75.05 mg/dL, iar PTH a avut valoarea medie ±1033 pg/ml. Ecografic, dimensiunea medie a paratiroidelor a fost de 1.0-3.0 cm.Toţi pacienţii au fost operaţi, înlăturânduse adenomul. Postoperator, s-a confirmat scăderea PTH şi normalizarea calciului seric. Concluzii. Diagnosticul pozitiv al HPP implică dozarea caciului seric şi a PTH. Adenomul este localizat prin USG, tratamentul chirurgical este singurul tratament curativ al HPP, mortalitatea postoperatorie a fost nulă.

Introduction. Primary hyperparathyroidism actualy represents a subject discussed in literature, which is characterized by hypersecretion of PTH and disappearance of feedback between the production of PTH and serum calcium level, which is related to adenoma in 95% of cases. Objective of the study. This study was performed for the assessment of clinical manifestations in HPP, informational eficiency of hormonal analysis, diagnostic methods and treatment. Material and methods. This retrospective study was performed on 24 patients, hospitalized in VAESurgery department, SCR during 2013-2016 years, diagnosed with primary HPP. Patients were evaluated clinically, paraclinically by using medical histories sheet and surgical protocols . Results. 24 cases with primary HPP were evaluated, 5 men (21%) and 19 women (79%), with mean age (50-70). Clinical manifestations: osteoarticular – 58.8%, n=14), renal – (25.2%, n=6), neuropsychological – (8.4%, n=2), digestive – (8.4%, n=2). Positive diagnosis: calcium level, mean calcium level was 12.1±0.47 mg/dL, phosphorus 500±75.05 md/dL, while PTH mean was ±1033 pg/ml. On echographic, mean size of pathological parathyroids was 1.0-3.0 cm. The surgical approach was performed in 100% cases. Conclusions. A positive diagnosis of HPP involves the determination of serum calcium, PTH. Localization of adenoma was performed via USG, choise of treatment – surgical. The post-operative mortality rate was null.