This research aims to globally analyze the impact of the geopolitical factor on the process of national and international security. The omission or the neglect of this factor does not lead to its disappearance; influence factors including geopolitical influence have an objective character existing regardless of political leaders’ will or the whole society’s will. The acceptance and knowledge of influence factors upon national and international security allows their management and maximum benefits gain for a national state.  The study presents the world politics where the members find themselves partially unable for security. Old tools and mechanisms to ensure internal security and regional concentration are ineffective. Liberalization and increased interstate cooperation in all social and political spheres lead involuntarily to the interdependence of member's security systems. States give up before some classical state powers through acts of will to ensure national and regional security.Regionalization processes attract national states in an interdependent security system in which security problems can not be separated by state borders. Security threats are common for a group of countries or region, and therefore actions designed to prevent and combat these threats must be shared. Each state decides on the format of a global partnership in this regard by including plenary political-military structure or establishing a special relationship with one of these organizations.  For Moldova, conflicts and tension between the two great powers is an opportunity, as long as they are focused upon their common mega problem, the state may improve its situation on the international arena. Moldova is located at the confluence of three politico-geographical regions: Central, Eastern and South-Eastern Europe. As a result, the MoldovanState assumes the status of a buffer state on the European continent between two structures competing in politico-military, economic and financial field. Political and diplomatic skillful management of Moldovan institutions will have tangible effects.