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Articolul precedent |
Articolul urmator |
719 12 |
Ultima descărcare din IBN: 2023-01-29 16:53 |
Căutarea după subiecte similare conform CZU |
615.273.53:616.36 (1) |
Medicamentele potrivit acţiunii lor principale (395) |
Patologia sistemului digestiv. Tulburări ale tubului alimentar (1732) |
SM ISO690:2012 DOGOT, Marta. Metabolizarea hepatică a clopidogrelului. In: Sănătate Publică, Economie şi Management în Medicină , 2017, nr. 4(74), pp. 104-106. ISSN 1729-8687. |
EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
Sănătate Publică, Economie şi Management în Medicină | ||||||
Numărul 4(74) / 2017 / ISSN 1729-8687 /ISSNe 2587-3873 | ||||||
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CZU: 615.273.53:616.36 | ||||||
Pag. 104-106 | ||||||
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Rezumat | ||||||
The purpose of the paper was to investigate the pathways of hepatic metabolism of clopidogrel by cytochrome P450 enzymes, depending on the genes encoding polymorphism. The bibliographic sources from 2001-2016 were explored in the databases: PubMed, Google Scholar, Cochrane. It was concluded that clopidogrel is biotransformed by the hepatic cytochrome P450 enzymes in its active metabolite. The pathway of biotransformation of clopidogrel into the active metabolite undergoes two oxidation steps, involving several enzymes of cytochrome P450, predominantly CYP3A4 and CYP2C19, which play a leading role in this process. Genes encoding cytochrome P450 enzymes may have different polymorphisms, producing enzymes with varying biotransformation activity of clopidogrel in the active metabolite. |
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Cuvinte-cheie clopidogrel, biotransformation, metabolite |
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