Studying the geopolitical architecture of the East-European space, one can say that this part of the globe is in the process of formation as a result of relations among the geopo­litical actors – power centers – the West represented by the US, NATO and EU on one hand and on the other hand the Russian Federation. Carefully analyzing the ongoing transformations within the East-European space, we can see that the contents of geopolitics centered on the ability of states to divide geographical space has been rapidly changed. This article analyzes for the first time the subject of the “new configuration of East-Euro­pean geopolitical architecture”. Integration processes like the EU and NATO eastward extensi­on, as well as integration / disintegration from the post-Soviet space, the events in the Eastern Ukraine that resulted in the annexation of Crimea and the city of Sevastopol by the Russian Federation have had a significant impact on the creation of the new geopolitical architecture of the East-European space.