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Ultima descărcare din IBN: 2024-04-23 10:19 |
SM ISO690:2012 HADJIU, Svetlana. Tratamentul leziunilor hipoxico-ischemice perinatale cu preparatul factor neurotrofic derivat din creier
. In: Curierul Medical, 2011, nr. 4(322), pp. 26-34. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 4(322) / 2011 / ISSN 1875-0666 | ||||||
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Pag. 26-34 | ||||||
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Treatment of Perinatal Hypoxic-Ischemic Injury with Brain-Derived Neurotrophic Factor
In this study, we analyzed the brain-derived neurotrophic factor (BDNF) in the serum of children with diverse grades of perinatal hypoxic-ischemic
injuries (PHIE) during treatment with BDNF (GUNA product). Higher levels of BDNF are associated with better protection against the degeneration of
the brain, a greater degree of neuronal survival and differentiation. Low BDNF levels in serum of newborns with PHIE constitute an objective criterion
in the prognosis of neuropsychical and motor disabilities. In severe PHIE the processes of neurogenesis are impeded and the cortical neurons are left
unprotected. In this case, a low BDNF level is not sufficient to maintain the processes of neurotrophicity and neuroregeneration. Treatment with large
numbers of exogenous neurotrophic factors protects sensitive cerebral tissues against hypoxic-ischemic injuries.
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Cuvinte-cheie brain-derived neurotrophic factor, Perinatal Hypoxic-Ischemic Encephalopathy, disorders of muscle tonus, children |
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