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Ultima descărcare din IBN: 2023-08-10 15:36 |
SM ISO690:2012 MORARU, Ion. Acţiunea precondiţionării hipoxice asupra unor indici ai stresului oxidativ
. In: Curierul Medical, 2011, nr. 4(322), pp. 42-46. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 4(322) / 2011 / ISSN 1875-0666 | ||||||
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Pag. 42-46 | ||||||
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The Hypoxic Precondition Action on Some Indices of the Oxidative Stress
The circulating levels of lipid peroxidation products such as lipid hydroperoxides and malonic dialdehyde as well as of several antioxidants such as
catalase, glutationreductase and ceruloplasmin have been found in the blood of 74 patients with arterial hypertension who underwent antihypertensive
treatment and had experienced hypoxic precondition. Likewise the expression and quantity of thioredoxin were found in human umbilical endothelial
cells exposed to progressive hypoxia using laser confocal microscopy and the Western Blot exam. Compared to samples obtained from patients who
received only antihypertensive treatment the hypoxic precondition led to a greater increase of antioxidants levels and to a deeper decline of products of
oxidative stress. Hypoxic precondition increased almost 7-fold the expression and quantity of the endotheliocyte thioredoxin.
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Cuvinte-cheie hypoxic precondition, thioredoxin, laser confocal microscopy, oxidative stress |
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