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Ultima descărcare din IBN: 2023-07-02 17:03 |
SM ISO690:2012 POPOVICI, Ion. Unele aspecte patogenetice ale hiperplaziei neointimei în cadrul restenozei intrastent
. In: Curierul Medical, 2011, nr. 3(321), pp. 55-60. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 3(321) / 2011 / ISSN 1875-0666 | ||||||
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Pag. 55-60 | ||||||
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Pathogenetic Aspects of the Neointima Hyperplasia in the in-stent Restenosis
Using the method of hybridization in situ, RT-PCR, confocal scanner microscopy and immunofluorescent microscopy with specific antibodies to matrix
metalloproteinase collagenase IV (MMP-2), we analyzed expression of tissue inhibitor (TIMMP-2) and mononuclear cell marker CD68 in restenosed coronary
tissue taken from 11 patients who died with in-stent restenosis (ISS). The expression and quantity of micro-ribonucleic acids (micro-RNA/145), MMP-2 and
TIMMP-2 were estimated, as well as the number of present macrophages. The micro-RNA/145 expression and quantity are reduced in ISS, and this reduction
is proportional to restenosis degree. On the other hand, the MMP-2 expression and quantity in the neointima are increased while that of TIMMP-2 is reduced.
With respect to the number of macrophages present in the neointima of ISS tissue, their number is greatly elevated in the areas affected by the restenosis.
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Cuvinte-cheie restenosis, micro-RNA/145, matrix metalloproteinase |
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