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SM ISO690:2012 RUDICO, Lucian, MAZURU, Vitalie, ŞAPTEFRAŢI, Lilian, DAVID, Valeriu. Macrophage Density Correlates with Severity of Uterine Cervix Neoplasia
. In: Curierul Medical, 2011, nr. 3(321), pp. 21-25. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 3(321) / 2011 / ISSN 1875-0666 | ||||||
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Despite all recent efforts, cancer of the uterine cervix still remains one of the most frequent malignancies among women. Lymphatic vessels represent
the primary route of tumor cells dissemination in cervical cancer. It has been demonstrated that cervical neoplasia actively participates in the recruitment
of new blood and lymphatic vessels. Macrophages are extremely versatile cells which have a significant contribution to tumor progression. The aim: 1)
To establish the correlation between tumor-associated macrophages (TAM) and the grade of the uterine cervix neoplasia; 2) To evaluate the distribution
of TAM within both intratumoral and peritumoral areas. Material and Methods: Ninety-six cases were studied. The specimens were fixed in buffered
formalin and paraffin embedded. Step sections, 5μm thick, were performed for each case. Initial sections were stained with haematoxylin-eosin, for
the pathological diagnosis and grading of the tumor. Lesions were classified as follows: squamous cell metaplasia (n = 12), CIN I (n = 8), CIN II (n =
6), CIN III (n = 24), microinvasive carcinoma (n = 16) and invasive squamous cell carcinoma (n = 26). Additional sections for each case were stained
for CD68 antibody, in order to highlight the macrophages. Quantification of macrophage population has been made based on hot-spot technique. The
arithmetic media of 3 (× 200) fields represented the final result. Results: We found a statistical correlation between peritumoral macrophages (PTM)
and intratumoral macrophages in all stages of cervical neoplasia, macrophage density and tumor stage (p = 0.01). In 16 cases we found vascular invasion.
Almost in all these cases (87.5%) intravascular tumor emboli were embedded with CD68 cells. Conclusions: based on these findings, we consider that
macrophages are key regulators of cervical cancer progression. TAM targeted management could be an essential therapeutic strategy, not only in order
to suppress the progression of cervical neoplasia, but also to inhibit macrophage-mediated vascular invasion.
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Cuvinte-cheie uterine cervix cancer, macrophages, cellular density, tumor progression, CD68 |
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