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Ultima descărcare din IBN: 2020-03-26 15:05 |
SM ISO690:2012 CHIRVAS, Elena, LUPAŞCO, Iulianna. Aspecte noi în imunopatogeneza hepatitei cronice virale B. In: Curierul Medical, 2011, nr. 3(321), pp. 48-54. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 3(321) / 2011 / ISSN 1875-0666 | ||||||
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Pag. 48-54 | ||||||
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Rezumat | ||||||
New Aspects in the Immunopathogenesis of Chronic Hepatites B
Successful clearance and resolution of infection depends on the age and immune status of the individual with most infections of immunocompetent
adults being self-limiting. Persistent or chronic infection is more likely to occur following vertical transmission (from mother to child) or horizontal
transmission to children or to immunocompromised adults. The immune determinants of successful clearance of HBV are not fully understood but
both cellular and humoral immune responses are important. At the same time, however, liver inflammation and disease are also believed to be largely
immune-mediated. Therefore, a comlex interaction exists between HBV and the host in the initial clearance of HBV, the long-term persistence of HBV
and the pathogenesis of HBV liver disease. There are some mechanisms of HBV-suppressing effect on immune response parts: exhaustion of virus-specific
CTL functional activity as a result of persistence of high concentrations of viral antigens; elevation of activity of regulatory T-cells; ability HBV to exist in
the form of sustained endocellular template – covalently closed circular DNA (ccc DNA). The role of activated platelets in immunopathological reactions
is also considered at chronic viral liver damage. |
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Cuvinte-cheie viral hepatitis B, innate immunodefence, adaptive immunodefence |
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