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Ultima descărcare din IBN: 2023-05-12 17:22 |
SM ISO690:2012 MOCANU, Natalia, SACARĂ, Victoria, GROPPA, Stanislav. Particularităţile formelor clinice şi posibilităţile de diagnostic al bolii Wilson în Republica Moldova. In: Curierul Medical, 2011, nr. 1(319), pp. 63-66. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 1(319) / 2011 / ISSN 1875-0666 | ||||||
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Pag. 63-66 | ||||||
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Peculiarity of Clinical Forms and Diagnostic Methods of Wilson’s Disease in the Republic of Moldova
Wilson’s disease (WD) is an autosomal recessive disorder of copper transport caused by a defect in the ATP7B gene. The disorder manifests
as chronic liver disease and/or neurological impairment due to accumulation of copper in several tissues, principally in the liver and brain. The
aim of the study was to evaluate the clinical forms and diagnostic methods of WD. We analyzed 35 Moldavan patients with WD. The diagnosis
was established in any patients with unexplained liver disease along with neurological or neuropsychiatric disorder, presenting of Kayser-Fleischer
rings, low serum ceruloplasmin level, the amount of copper excreted in the urine in a 24-hour period. Functional hepatic tests and others date
of laboratory was obtained with standard methods. Initial clinical manifestation were hepatic in 10 (28.6%) patients, 19 (54.3%) were with
neurological disorder, 6 (17.1%) patients presented mix hepatic and neuropsychiatric disturbance. Only in 2 (5.7%) patients the initial clinical
manifestation was with psychiatric disturbance. Of the patients with neurological and mix disorder, 10 (40%) were with moderate liver disorder
and only 5 (20%) with chronic liver disease. The neurological function was categoriezed as severe in 11 (44%) cases and moderate in 13 (52%)
patients. Of the Moldovan patients, 71% have mix hepatic and neuropsychiatric forms with predomination of neurological disturbance average
of 20 years. The difficulty in family screening could be solved with access to molecular diagnosis. |
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Cuvinte-cheie Wilson disease, ATP7B gene, ceruloplasmin, autosomal recessive |
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