Viability and proliferation of endothelial cells upon exposure to GaN nanoparticles
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BRANIŞTE, Tudor; TIGINYANU, Ion; HORVÁTH, Tibor; RAEVSCHI, Simion; CEBOTARI, Serghei; LUX, Marco; HAVERICH, Axel; HILFIKER, Andres. Viability and proliferation of endothelial cells upon exposure to GaN nanoparticles. In: Beilstein Journal of Nanotechnology. 2016, nr. 1(7), pp. 1330-1337. ISSN 2190-4286.
10.3762/bjnano.7.124
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Beilstein Journal of Nanotechnology
Numărul 1(7) / 2016 / ISSN 2190-4286

Viability and proliferation of endothelial cells upon exposure to GaN nanoparticles


DOI: 10.3762/bjnano.7.124
Pag. 1330-1337

Branişte Tudor12, Tiginyanu Ion1, Horváth Tibor2, Raevschi Simion3, Cebotari Serghei2, Lux Marco2, Haverich Axel2, Hilfiker Andres2
 
1 Technical University of Moldova,
2 Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School,
3 State University of Moldova
 
Disponibil în IBN: 18 decembrie 2017


Rezumat

Nanotechnology is a rapidly growing and promising field of interest in medicine; however, nanoparticle-cell interactions are not yet fully understood. The goal of this work was to examine the interaction between endothelial cells and gallium nitride (GaN) semiconductor nanoparticles. Cellular viability, adhesion, proliferation, and uptake of nanoparticles by endothelial cells were investigated. The effect of free GaN nanoparticles versus the effect of growing endothelial cells on GaN functionalized surfaces was examined. To functionalize surfaces with GaN, GaN nanoparticles were synthesized on a sacrificial layer of zinc oxide (ZnO) nanoparticles using hydride vapor phase epitaxy. The uptake of GaN nanoparticles by porcine endothelial cells was strongly dependent upon whether they were fixed to the substrate surface or free floating in the medium. The endothelial cells grown on surfaces functionalized with GaN nanoparticles demonstrated excellent adhesion and proliferation, suggesting good biocompatibility of the nanostructured GaN.

Cuvinte-cheie
Endothelial cells, GaN nanoparticles,

Proliferation, Surface functionalization