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SM ISO690:2012 GHICAVÂI, Victor, COREŢCHI, Ianoş. Acţiunea profeturului asupra parametrilor principali ai hemodinamicii sistemice. In: Sănătate Publică, Economie şi Management în Medicină , 2014, nr. 1(52), pp. 45-50. ISSN 1729-8687. |
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Sănătate Publică, Economie şi Management în Medicină | |||||
Numărul 1(52) / 2014 / ISSN 1729-8687 /ISSNe 2587-3873 | |||||
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Pag. 45-50 | |||||
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Research aims to evaluate the action of the new derivative of the alkylisothiourea – profetur in the dose of 5 mg/kg on indices of systemic hemodynamics in normal conditions, and on the background of ganglion blockade with hexamethonium in the dose of 10 mg/kg in anesthetized cats. In normotensive conditions single dose administration of the profetur showed pronounced and long-term (more than 60 min.) hypertensive action, driven by increased peripheral vascular resistance, minute-volume, stroke volume, and circulating blood volume. Single dose intravenous administration of the profetur on the background of ganglion blockade induced with hexamethonium is followed by stabilization of the blood pressure’s values and removing of hemodynamic disturbances caused by ganglioblocker. |
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Cuvinte-cheie profetur, hexamethonium, systemic hemodynamics. |
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