Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
822 0 |
SM ISO690:2012 BOTHAMLEY, Graham Henry, LANGE, Christoph G., ALBRECHT, Dirk, ANIBARRO, Luis, GOMEZ, Neus Altet, ANDERSEN, Aase Bengaard, AVSAR, Korkut, BALASANYANTS, Goar, BELTON, Moerida, GARCIA, Cristina Berastegui, BOGYI, Matthias, BRUCHFELD, Judith, CAMINERO, Jose Antonio, CHESOV, Dumitru, CHIAPPINI, Elena, CONFALONIERI, Marco, DEDICOAT, Martin John, LUIZA DE SOUZA-GALVAO, Maria, DUARTE, Raquel, DUDNYK, Andrii, DYRHOL-RIISE, Anne Ma A., EISENHUT, Michael, ESTEBAN, Jaime, FLOE, Andreas, GARCIA-GARCIA, Jose Maria. Infection control, genetic assessment of drug resistance and drug susceptibility testing in the current management of multidrug/extensively-resistant tuberculosis (M/XDR-TB) in Europe: A tuberculosis network European Trialsgroup (TBNET) study. In: Respiratory Medicine, 2017, nr. 132, pp. 68-75. ISSN 0954-6111. DOI: https://doi.org/10.1016/j.rmed.2017.09.007 |
EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
Respiratory Medicine | |
Numărul 132 / 2017 / ISSN 0954-6111 /ISSNe 1532-3064 | |
|
|
DOI:https://doi.org/10.1016/j.rmed.2017.09.007 | |
Pag. 68-75 | |
Rezumat | |
Aim Europe has the highest documented caseload and greatest increase in multidrug and extensively drug-resistant tuberculosis (M/XDR-TB) of all World Health Organization (WHO) regions. This survey examines how recommendations for M/XDR-TB management are being implemented. Methods TBNET is a pan-European clinical research collaboration for tuberculosis. An email survey of TBNET members collected data in relation to infection control, access to molecular tests and basic microbiology with drug sensitivity testing. Results 68/105 responses gave valid information and were from countries within the WHO European Region. Inpatient beds matched demand, but single rooms with negative pressure were only available in low incidence countries; ultraviolet decontamination was used in 5 sites, all with >10 patients with M/XDR-TB per year. Molecular tests for mutations associated with rifampicin resistance were widely available (88%), even in lower income and especially in high incidence countries. Molecular tests for other first line and second line drugs were less accessible (76 and 52% respectively). A third of physicians considered that drug susceptibility results were delayed by > 2 months. Conclusion Infection control for inpatients with M/XDR-TB remains a problem in high incidence countries. Rifampicin resistance is readily detected, but tests to plan regimens tailored to the drug susceptibilities of the strain of Mycobacterium tuberculosis are significantly delayed, allowing for further drug resistance to develop. |
|
Cuvinte-cheie Drug-resistance, Europe, Infection control, PCR, tuberculosis |
|
|
DataCite XML Export
<?xml version='1.0' encoding='utf-8'?> <resource xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xmlns='http://datacite.org/schema/kernel-3' xsi:schemaLocation='http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd'> <identifier identifierType='DOI'>10.1016/j.rmed.2017.09.007</identifier> <creators> <creator> <creatorName>Bothamley, G.</creatorName> <affiliation>Homerton University Hospital, Marea Britanie</affiliation> </creator> <creator> <creatorName>Lange, C.</creatorName> <affiliation>Centrul de Cercetare din Borstel, Germania</affiliation> </creator> <creator> <creatorName>Albrecht, D.</creatorName> <affiliation>Sunderby Hospital, Lulea, Suedia</affiliation> </creator> <creator> <creatorName>Anibarro, L.</creatorName> <affiliation>Completo Hospitalario de Pontevedra, Spania</affiliation> </creator> <creator> <creatorName>Gomez, N.</creatorName> <affiliation>Unidad de Tratamiento Directamente Observado Serveis Clinics, Barcelona, Spania</affiliation> </creator> <creator> <creatorName>Andersen, A.</creatorName> <affiliation>Rigshospitalet, Danemarca</affiliation> </creator> <creator> <creatorName>Avsar, K.</creatorName> <affiliation>Asklepios Fachklinik, München-Gauting, Germania</affiliation> </creator> <creator> <creatorName>Balasanyants, G.</creatorName> <affiliation>Saint Petersburg Research Institute of Phthesiopulmonology, Rusia</affiliation> </creator> <creator> <creatorName>Belton, M.</creatorName> <affiliation>Lewisham and Greenwich NHS Trust, London, Marea Britanie</affiliation> </creator> <creator> <creatorName>Garcia, C.</creatorName> <affiliation>Servei Pneumologia, Hospital Universitari, Vall d'Hebron, Barcelona, Spania</affiliation> </creator> <creator> <creatorName>Bogyi, M.</creatorName> <affiliation>Wilhelminspital, Wien, Austria</affiliation> </creator> <creator> <creatorName>Bruchfeld, J.</creatorName> <affiliation>Karolinska University Hospital, Stockholm, Suedia</affiliation> </creator> <creator> <creatorName>Caminero, J.</creatorName> <affiliation>Hospital General Gran Canaria “Dr. Negrin”, Las Palmas, Spania</affiliation> </creator> <creator> <creatorName>Chesov, D.I.</creatorName> <affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation> </creator> <creator> <creatorName>Chiappini, E.</creatorName> <affiliation>Meyer University Hospital, Florence, Italia</affiliation> </creator> <creator> <creatorName>Confalonieri, M.</creatorName> <affiliation>University Hospital of Trieste, Italia</affiliation> </creator> <creator> <creatorName>Dedicoat, M.</creatorName> <affiliation>Heart of England NHS Foundation Trust, Birmingham, Marea Britanie</affiliation> </creator> <creator> <creatorName>Luiza De Souza-Galvao, M.</creatorName> <affiliation>Unitat de Tuberculosis, Vall d'Hebron, Spania</affiliation> </creator> <creator> <creatorName>Duarte, R.</creatorName> <affiliation>University of Porto, Portugalia</affiliation> </creator> <creator> <creatorName>Dudnyk, A.</creatorName> <affiliation>Винницкий национальный медицинский университет им. Н. И. Пирогова, Винница, Ucraina</affiliation> </creator> <creator> <creatorName>Dyrhol-Riise, A.</creatorName> <affiliation>Oslo University Hospital, Norvegia</affiliation> </creator> <creator> <creatorName>Eisenhut, M.</creatorName> <affiliation>Luton and Dunstable University Hospital, Luton, Marea Britanie</affiliation> </creator> <creator> <creatorName>Esteban, J.</creatorName> <affiliation>Department of Clinical Microbiology, IIS-Fundacion Jiminez Diaz, Madrid, Spania</affiliation> </creator> <creator> <creatorName>Floe, A.</creatorName> <affiliation>Aarhus University Hospital, Aarhus, Danemarca</affiliation> </creator> <creator> <creatorName>Garcia-Garcia, J.</creatorName> <affiliation>Hospital San Agustin, Avilés, Spania</affiliation> </creator> </creators> <titles> <title xml:lang='en'>Infection control, genetic assessment of drug resistance and drug susceptibility testing in the current management of multidrug/extensively-resistant tuberculosis (M/XDR-TB) in Europe: A tuberculosis network European Trialsgroup (TBNET) study</title> </titles> <publisher>Instrumentul Bibliometric National</publisher> <publicationYear>2017</publicationYear> <relatedIdentifier relatedIdentifierType='ISSN' relationType='IsPartOf'>0954-6111</relatedIdentifier> <subjects> <subject>Drug-resistance</subject> <subject>Europe</subject> <subject>Infection control</subject> <subject>PCR</subject> <subject>tuberculosis</subject> </subjects> <dates> <date dateType='Issued'>2017-11-08</date> </dates> <resourceType resourceTypeGeneral='Text'>Journal article</resourceType> <descriptions> <description xml:lang='en' descriptionType='Abstract'><p>Aim Europe has the highest documented caseload and greatest increase in multidrug and extensively drug-resistant tuberculosis (M/XDR-TB) of all World Health Organization (WHO) regions. This survey examines how recommendations for M/XDR-TB management are being implemented. Methods TBNET is a pan-European clinical research collaboration for tuberculosis. An email survey of TBNET members collected data in relation to infection control, access to molecular tests and basic microbiology with drug sensitivity testing. Results 68/105 responses gave valid information and were from countries within the WHO European Region. Inpatient beds matched demand, but single rooms with negative pressure were only available in low incidence countries; ultraviolet decontamination was used in 5 sites, all with >10 patients with M/XDR-TB per year. Molecular tests for mutations associated with rifampicin resistance were widely available (88%), even in lower income and especially in high incidence countries. Molecular tests for other first line and second line drugs were less accessible (76 and 52% respectively). A third of physicians considered that drug susceptibility results were delayed by > 2 months. Conclusion Infection control for inpatients with M/XDR-TB remains a problem in high incidence countries. Rifampicin resistance is readily detected, but tests to plan regimens tailored to the drug susceptibilities of the strain of Mycobacterium tuberculosis are significantly delayed, allowing for further drug resistance to develop.</p></description> </descriptions> <formats> <format>uri</format> </formats> </resource>