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616.37-002.2:577.22:614.2(478) (1) |
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SM ISO690:2012 BUGAI, Rodica, ŢÎBÎRNĂ, Ion, BARBACAR, Nicolae. Relevanţa unor factori de risc genetici şi a stresului oxidativ la pacienţii cu pancreatită cronică latentă din Republica Moldova. In: Sănătate Publică, Economie şi Management în Medicină , 2015, nr. 4(61), pp. 125-129. ISSN 1729-8687. |
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Sănătate Publică, Economie şi Management în Medicină | |||||
Numărul 4(61) / 2015 / ISSN 1729-8687 /ISSNe 2587-3873 | |||||
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CZU: 616.37-002.2:577.22:614.2(478) | |||||
Pag. 125-129 | |||||
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The purpose of the study was to evaluate the relevance of oxidative stress (OS) and some genetic factors in patients with latent chronic pancreatitis (LCP). The study included 38 patients with LCP, male/female – 20/18, median age 49,17±1,21 years and the control group (CG) included 100 practically healthy persons. It has been proven that LCP in RM is a pathology with a clear genetic background through the presence of mutated genes included in the study in 97,37% of patients; mutations of the following genes have been confirmed: PRSS1 (R112C) – in 25 pts. (65,79%), SPINK1 (N34S) – in 28 pts. (73,68%), CTFR (R117H) – in 31 pts. (81,57%), vs CG: PRSS1 (R112C) – in 63 pts. (63%); SPINK1 (N34S) – in 74 pts. (74%); CFTR (R117H) – in 53 pts. (53%), the differences being statistically significant, p<0,001. It has been proven that OS has an important role in the mechanism and evolution of LCP through the growth of lipid peroxidation activity (conjugated dienes and trienes, Shiff bases in the hexanic and isopropanolic phases, malonic dialdehide) and the reduction of antioxidant system activity (total antioxidant activity in the hexanic and isopropanolic phases, superoxiddismutase, catalase, glutationreductase). |
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Cuvinte-cheie chronic pancreatitis, oxidative stress, PRSS1, SPINK1, CFTR |
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