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577.1:616.65-002-092 (1) |
Bazele materiale ale vieții. Biochimie. Biologie moleculară. Biofizică (664) |
Patologia sistemului urogenital. Boli urinare şi sexuale (genitale) (392) |
SM ISO690:2012 TĂNASE, Adrian, BOBU, Victor, GUDUMAC, Valentin, PLEŞCA, Eduard, CARAION, Vladimir, COSTENCO, E., GUŢU, Constantin. Particularităţile activităţii enzimelor lizozomale din serul sangvin în adenomul prostatic şi la nivelul lojei după adenomectomia transvezicală cu utilizarea drenului endouretral al lojei. In: Sănătate Publică, Economie şi Management în Medicină , 2016, nr. 2(66), pp. 121-124. ISSN 1729-8687. |
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Sănătate Publică, Economie şi Management în Medicină | ||||||
Numărul 2(66) / 2016 / ISSN 1729-8687 /ISSNe 2587-3873 | ||||||
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CZU: 577.1:616.65-002-092 | ||||||
Pag. 121-124 | ||||||
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The mechanisms by which lysosomal disorders affecting prostate functions in prostate adenoma News. The mechanisms by which lysosomal disorders affecting prostate functions in prostate adenoma bulky (APV), including the Lodge of adenomectomy are poorly understood, and the effectiveness of current therapeutic measures are limited and uncertain. The research is based on two study groups: Lb – patients with a mean age of 68.6±1.05 and bulky AP definite diagnosis (≥ 80 cm3) repair surgery using drainage endouretralnye and Lm – 20 men of the same age, basically healthy. Lysosomal enzyme activity determination (Cat G rnd CatD; FA; NAG; β -gal, β-gul, and β-glucuronidase, arylsulfatase A and B, total protein was performed by standard techniques, adapted for application to multi-modal hybrid rider microplate Synergy H1 (Reader Hydride). As a result it was determined that AP ≥ 80 m3 bulky significantly induce the growth of all lysosomal enzymes studied, reaching values of 2-3 times higher compared with controls, with the prevalence of high values of 4-6 times, β –gal, ß-gluc and CatG fact catgut as coexistent inflammatory process caused by the presence of biological membranes and destabilization celulare. Sa direct interdependencies found the presence of liposomal enzymes in their blood serum and deletions to the lodge postoperative which can serve as a biomarker of evolution postoperative period, with predictive role in assessing the effectiveness of the treatment strategy and local general medical and surgical, monitoring and optimization of rehabilitation of patients with AP and adenomectomy |
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Cuvinte-cheie lysosomal enzymes, surgery, prostatic adenoma, drainage of adeomectomie lodge |
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