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Ultima descărcare din IBN: 2024-01-16 11:48 |
Căutarea după subiecte similare conform CZU |
577.17:616.36-002 (1) |
Bazele materiale ale vieții. Biochimie. Biologie moleculară. Biofizică (664) |
Patologia sistemului digestiv. Tulburări ale tubului alimentar (1732) |
SM ISO690:2012 LUPAŞCO, Iulianna, DUMBRAVA, Vlada-Tatiana, ROMANCIUC (VENGHER), Inna, TARAN, Natalia, BURDA, Tatiana, TOCAN, Alina, URSACHII, Cristina, CEBANU, Ecaterina, CUMPĂTĂ, Veronica, RĂILEANU, Ludmila. Nucleotidele ciclice și patologia hepatica . In: Sănătate Publică, Economie şi Management în Medicină , 2016, nr. 4(68), pp. 65-69. ISSN 1729-8687. |
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Sănătate Publică, Economie şi Management în Medicină | ||||||
Numărul 4(68) / 2016 / ISSN 1729-8687 /ISSNe 2587-3873 | ||||||
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CZU: 577.17:616.36-002 | ||||||
Pag. 65-69 | ||||||
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Cyclic nucleotides (CN) cAMP and cGMP are recognized as cell signaling molecules that control a variety of biological processes such as cell growth and adhesion, energy homeostasis, neuronal signaling and muscle relaxation. The alterations of CN signals were being observed in a number of pathophysiologic conditions, including liver disorders. In the liver, cAMP is distributed along the sinusoids and cGMP – in the nuclear elements and membranes of the hepatocytes. Their role is to mobilize the reserves of glucose and fatty acids from peripheral tissues. Alterations in the intracellular signaling process by cAMP has been shown to be involved in the pathological changes in colangiocyte: cholestatic secretory disorders and disorders associated with changes in cell proliferation, hepatocyte: advanced fi brotic processes as cirrhosis (CH), hepatocellular carcinoma (HCC). Cyclic AMP and cGMP can exert a stimulatory or inhibitory effect on cell proliferation depending on the cell type. This would suggest that disruption of intracellular signaling plays an important role in carcinogenesis. In patients with primary HCC were determined high serum levels of cAMP and cGMP. This data show the importance of studying CN as a potential cornerstone in the treatment of fibrotic processes and oncological pathologies, given the growing prevalence of this diseases worldwide, including in Moldova which leads after CH mortality index of the 192 |
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Cuvinte-cheie cyclic nucleotides, liver disease |
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