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[616.36+616.348-002.44](478) (1) |
SM ISO690:2012 JUCOV, Alina, ŢURCAN, Svetlana. Dinamica frecvenţei și spectrului patologiei hepatice la pacienţii cu colită ulcerativă pe parcurs de 15 ani în Republica Moldova. In: Sănătate Publică, Economie şi Management în Medicină , 2016, nr. 4(68), pp. 16-18. ISSN 1729-8687. |
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Sănătate Publică, Economie şi Management în Medicină | ||||||
Numărul 4(68) / 2016 / ISSN 1729-8687 /ISSNe 2587-3873 | ||||||
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CZU: [616.36+616.348-002.44](478) | ||||||
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Ulcerative Colitis (UC) is a systemic disease associated with a significant number of extraintestinal manifestations (EIM). Hepatic manifestations are not uncommon in IBD. The aim of the study was to compare the frequency and spectrum of liver pathology in patients with UC in cohort from 1998-2000 (cohort I) and 2014- 2015 (cohort II) in Moldova – the region with very unfavorable indices of morbidity and mortality from liver diseases. The study was open prospective and included 129 patients with UC (52% female, age of 18-65 years) in cohort I and 230 patients (56% female, age of 18-67 years) in cohort II. Liver diseases were diagnosed in 24,8% (32) of cases in the first cohort: steatosis – 8,5% (11); chronic viral HBV infection – 7,0% (9); chronic hepatitis C – 2,3% (3); reactive and drug induced hepatitis – 6,2% (8); primary sclerosing cholangitis – 0,8% (1); bacterial cholangitis – 0,8% (1); chronic viral B cirrhosis 0,8% (1). In the second cohort diseases of the liver were observed in 26,5% (61) of cases: steatosis – 7,0% (16), chronic viral HBV infection – 8,3% (19), inclusive chronic hepatitis B HBV- DNA positive – 2,2% (5); chronic viral hepatitis C – 3,9% (9); reactive hepatitis – 3,0% (7); drug induced hepatitis – 0,4% (1); autoimmune hepatitis – 0,4% (1); primary sclerosing cholangitis – 0,4% (1); primary biliary cirrhosis – 0,4% (1); chronic viral C cirrhosis – 0,9% (2). No significant changes were observed in the frequency and spectrum of liver diseases in UC for the past 15 years |
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Cuvinte-cheie ulcerative colitis, liver disorders, hepatitis B and C |
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