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SM ISO690:2012 VLASOV, Lilia, MATCOVSCHI, Serghei, TCACIUC, Eugen, SASU, Boris. Evaluarea unor factori patogenetici, ce contribuie la instalarea complicaţiilor renale la pacienţii cu ciroze hepatice. In: Curierul Medical, 2010, nr. 3(315), pp. 133-136. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 3(315) / 2010 / ISSN 1875-0666 | ||||||
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Pag. 133-136 | ||||||
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Evaluation of Pathogenetic Factors that Contribute to Renal Complications in Patients with Cirrhosis
The study involved 82 patients - 40 women and 42 men. Early detection of renal function impairment is a major predictive importance in
managing patients with liver cirrhosis. In liver cirrhosis Child-Pugh class C, the renal hemodynamics is already compromised and is characterized
by growth of vasoconstrictor factors. Azotemia in acute renal failure in hepato-renal syndrome does not reach very high values and is not associated
with severe hyperpotassemia. PGE2 synthesis in the kidney is progressively inhibited by renal hemodynamic disturbances with advancing liver
cirrhosis, which translates into decreasing PGE-1 levels in the serum. E1 is the vasoconstrictor with the most increased levels in patients with
liver cirrhosis Child-Pugh class C and particularly in patients with hepato-renal syndrome. The decreased glomerular filtration rate is associated
with an increased amount of ET-1, low sodium in the blood and edema in patients with refractory ascites. |
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Cuvinte-cheie liver cirrhosis, renal hemodynamics, hepato-renal syndrome |
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