Background: Cardiovascular disease is the leading cause of mortality at the global and national level. Ischeamic heart diseases, cerebrovascular diseases and hypertensive heart disease together identify a highest proportional mortality that defines them as major contribution cardiovascular diseases worldwide. Premature mortality analyzing compared to traditional moves target from classical focus on the occurrence of deaths to focus on the losses caused by these deaths. The purpose of the study is to assess the premature mortality evolution from major cardiovascular diseases among adults in the Republic of Moldova for the period of 2003-2015. Material and methods: the research is a descriptive population study over the time of 13 years. The premature mortality phenomenon was counted in the years of potential life lost (YPLL). Age-adjusted rates were calculated using the direct method of standardization applying WHO World Standard Population Distribution (%) based on world average population between 2000-2025. Results: Overall period from 2003 to 2015, premature mortality rate from ischeamic heart diseases (+10.7%) and hypertensive heart disease (+41%) have registered increasing trends versus premature mortality rate from cerebrovascular diseases with decreasing trend (-23.9%). All together determined the decreasing trend (-2.4%) of major cardiovascular diseases premature mortality rate. When analyzing percentage changes of premature mortality increasing trends by age, the study findings identified the higher percentage changes in younger groups for ischeamic heart diseases premature deaths than hypertensive heart disease. Conclusions: Despite the general decreasing trend of major cardiovascular diseases premature mortality rate, ischemic heart diseases compared to cerebrovascular and hypertensive heart disease identify the most pronounced trends of the deaths event rejuvenation in the Republic of Moldova for the period 2003-2015.