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SM ISO690:2012 ДУБИНИНА, Владлена, РЫБИН, А., КУЗНЕЦОВА, О., ЛЫСЕНКО, М.. Дизрегуляционная патология у больных платинорезистентностным раком яичников
. In: Buletin de Perinatologie, 2014, nr. 1(61), pp. 10-15. ISSN 1810-5289. |
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Buletin de Perinatologie | ||||||
Numărul 1(61) / 2014 / ISSN 1810-5289 | ||||||
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Pag. 10-15 | ||||||
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Diagnosis and treatment of malignant ovarian tumors remains one of the most complicated problems of Gynecologic Oncology. Despite the high sensitivity of many diagnostic method, is insufficient specificity for differentiating benign and malignant tumors of the ovary. The aim of the study was the comparative analysis of the sensitivity of ovarian adenocarcinoma with stage IC – IIIC to adjuvant chemotherapy with platinum drugs depending on the state of the nitric oxide system in the body of patients, which is one of the markers of pathology and sanogenesis status. Materials and methods: A comparative analysis was performed of 54 clinical cases of ovarian cancer in stage IC - IIIC which have undergone optimal or suboptimal cytoreductive surgery. In all cases histological variant of ovarian cancer was adenocarcinoma. Criteria for assigning patients into groups was the sensitivity of ovarian cancer to platinum drugs. In group I included patients with ovarian cancer recurrence within 3 years. In group II, 22 patients were included in the missed ovarian cancer recurrence during 5 years of surveillance. Results and conclusions: The study was found significant decrease of nitric oxide system activity in patients with ovarian adenocarcinoma resistant to platinum dishes, which is an index of sanogenesis reduction in these patients. Status of nitric oxide system in patients body influences the susceptibility or resistance of tumors to chemotherapy with platinum preparations. |
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