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SM ISO690:2012 HLISTUN, Victoria, ŞIROCOVA, Natalia, UŞURELU, Natalia, EGOROV, Vladimir, PARII, Angela, MUNTEAN, Angela. Genele de faza a II-a (GSTM1, GSTT1, GSTP1) a detoxificării xenobioticelor la femei cu pierderi reproductive din Republica Moldova. In: Buletin de Perinatologie, 2014, nr. 1(61), pp. 47-52. ISSN 1810-5289. |
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Buletin de Perinatologie | ||||||
Numărul 1(61) / 2014 / ISSN 1810-5289 | ||||||
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Pag. 47-52 | ||||||
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Background: Recurrent pregnancy loss (RPL) is a multifactor and distressing disease. There are still approximately half of the RPL patients with cause not being identified to date. Is supposed that genetic polymorphisms in glutathione S-transferases (GSTs) may be associated with the risk of recurrent pregnancy loss. In this study, we aimed to investigate the relationship between the polymorphism of GSTM1, GSTT1, GSTP1 and the pregnancy loss. Methods: A case–control study of 100 cases with RPL and 100 healthy women was conducted. Was investigated DNA of 100 healthy children aged up to 17 years, in order to make a comparative analysis of GST polymorphisms in Moldova with other countries. They were genotyped for polymorphisms of GSTM1, GSTT1 and GSTP1 using PCR, PCR/RLFP methods. Results: We found that the frequencies of genotypes between cases and controls have no significant difference (p>0.05). 43% of the cases with RPL and 51% of the controls had the GSTM1 null genotype [odds ratio (OR)=0.72, 95% confidence interval (CI)=0.49-1.07)]. On the other hand, 28% of the cases and 35% of the controls had the GSTT1 null genotype (OR = 0.72; 95% CI=0.47-1.10). The frequency of GSTP1 gene of the cases and control is the following: GSTP1 Ile/Ile–49% and 51% (OR=0.92; 95%CI=0.53-1.71); GSTP1 Ile/Val–42% and 43% (OR=0.96; 95%CI=0.55-1.68); GSTP1 Val/Val–9% and 6% (OR=1.55; 95%CI=0.53-4.53). However, the differences in genotype frequencies between the study and control group are not statistically significant (P>0.05). The comparative analysis performed in the healthy population of Moldova and other countries have found that the frequency of GSTM1 null genotype in Moldova (50%) is similar to that in Ukraine, Italy, Russia, Egypt and Brazil (p>0.05), The frequencies of genotypes GSTT1( ) and GSTT1 0/0 in the Moldavian population are 64% and 36%, respectively differ significantly from the population investigated previously (p<0.05). Frequency of the GSTP1 polymorphism (GSTP1 Ile/Ile=37%; GSTP1 Ile/Val=53%; GSTP1 Val/Val=10%) differs from the same data in Ukraine, Russia and Turkey |
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Cuvinte-cheie The polymorphism of GSTM1, GSTT1, GSTP1 cannot be associated with the risk of recurrent pregnancy loss in Moldovan women. |
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