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SM ISO690:2012 TABUICA, Oleg. Aspecte contemporane ale diagnosticului serologic în sifilis
. In: Curierul Medical, 2009, nr. 6(312), pp. 28-32. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 6(312) / 2009 / ISSN 1875-0666 | ||||||
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Pag. 28-32 | ||||||
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Modern Aspects of the Serological Diagnosis of Syphilis
The paper is devoted to the differential diagnosis of early latent syphilis and false positive results. Serological tests for syphilis continue to play a major
role in the diagnosis and management of the disease and often are the only practical means of diagnosis. The problem acquires special importance in
consideration of the high rate of syphilis morbidity in the Republic of Moldova, associated with an enhanced percentage of latent syphilis. Serological
tests for syphilis are divided into 2 categories, nontreponemal and treponemal, according to the type of antigen used in the test. The antibodies detected
by nontreponemal tests are not only produced as a consequence of treponemal infection but also in response to other conditions in which tissue damage
occurs. These nonspecific reactions are usually referred to as biological false positives. Ideally, the confirmatory treponemal tests should have a high
sensitivity and specificity in order to identify any false positive values. Recent studies suggest that Western blot (immunoblotting) is considered the
most specific treponemal test and must be used as an alternative to other tests - TPHA (Treponema pallidum haemagglutination assay), EIA (Enzyme
immunoassay), FTA-abs (Fluorescent treponemal antibody-absorbed test) - when these tests give equivocal or conflicting results.
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Cuvinte-cheie syphilis serology, false positive results, immunoblotting |
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