Substituted 1,3-phenyl(pyridyl) propenones and derivatives with thiosemicarbazidic groups. Structrure – (hl-60) antileukemia activity relationship
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POPUSHOI, Ana; GULEA, Aurelian; BARBA, Nicanor; ROY, Jenny; POIRIER, Donald. Substituted 1,3-phenyl(pyridyl) propenones and derivatives with thiosemicarbazidic groups. Structrure – (hl-60) antileukemia activity relationship. In: Chemistry Journal of Moldova. 2014, nr. 2(9), pp. 67-73. ISSN 1857-1727.
10.19261/cjm.2014.09(2).10
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Chemistry Journal of Moldova
Numărul 2(9) / 2014 / ISSN 1857-1727 /ISSNe 2345-1688

Substituted 1,3-phenyl(pyridyl) propenones and derivatives with thiosemicarbazidic groups. Structrure – (hl-60) antileukemia activity relationship

CZU: [547+544+579.61]:615.12
DOI: 10.19261/cjm.2014.09(2).10
Pag. 67-73

Popushoi Ana1, Gulea Aurelian1, Barba Nicanor1, Roy Jenny2, Poirier Donald2
 
1 State University of Moldova,
2 CHUL Research Center (Université Laval)
 
Proiect:
INTAS 2004-78-7193 Imaging GaAs X-ray Detectors
 
Disponibil în IBN: 27 martie 2017


Rezumat

3-(4-(Dimethylamino)phenyl-1-(4-isothiocyanatophenyl)prop-2-en-1-one was obtained from the corresponding N,N-dimethylthyoureas by elimination of dimethylamine at heating with gaseous hydrogen chloride in chloroform and 1-(4-isothiocyanatophenyl)-3-(pyridin-2-il)prop-2-en-1-one by treating 1,1-dimethyl-3-(4-(3-(pyridin-2-il)-acryloyl)-phenyl)thyourea with acetic anhydride. For all obtained compounds in the course of reaction the antileukemia activity was investigated

Cuvinte-cheie
chalcones, isothiocyanatopropenones, thioureas, antileukemia activity

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<dc:creator>Popuşoi, A.</dc:creator>
<dc:creator>Gulea, A.P.</dc:creator>
<dc:creator>Barbă, N.</dc:creator>
<dc:creator>Roy, J.</dc:creator>
<dc:creator>Poirier, D.</dc:creator>
<dc:date>2014-01-01</dc:date>
<dc:description xml:lang='en'>3-(4-(Dimethylamino)phenyl-1-(4-isothiocyanatophenyl)prop-2-en-1-one was obtained from the corresponding N,N-dimethylthyoureas by elimination of dimethylamine at heating with gaseous hydrogen chloride in chloroform and 1-(4-isothiocyanatophenyl)-3-(pyridin-2-il)prop-2-en-1-one by treating 1,1-dimethyl-3-(4-(3-(pyridin-2-il)-acryloyl)-phenyl)thyourea with acetic anhydride. For all obtained compounds in the course of reaction the antileukemia activity was investigated</dc:description>
<dc:identifier>10.19261/cjm.2014.09(2).10</dc:identifier>
<dc:source>Chemistry Journal of Moldova 9 (2) 67-73</dc:source>
<dc:subject>chalcones</dc:subject>
<dc:subject>isothiocyanatopropenones</dc:subject>
<dc:subject>thioureas</dc:subject>
<dc:subject>antileukemia activity</dc:subject>
<dc:title>Substituted 1,3-phenyl(pyridyl) propenones and derivatives with thiosemicarbazidic groups. Structrure – (hl-60) antileukemia activity relationship</dc:title>
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