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616.33-008.1-031-08 (1) |
Patologia sistemului digestiv. Tulburări ale tubului alimentar (1732) |
SM ISO690:2012 SCURTU, Alina, ISTRATI, Valeriu, SCORPAN, Anatolie, GAVRILIUC, Svetlana. Rolul polimorfismului genelor sintazelor oxidului nitric in boala de reflux gastroesofagian. In: Arta Medica , 2016, nr. 2(59), pp. 33-35. ISSN 1810-1852. |
EXPORT metadate: Google Scholar Crossref CERIF DataCite Dublin Core |
Arta Medica | ||||||
Numărul 2(59) / 2016 / ISSN 1810-1852 /ISSNe 1810-1879 | ||||||
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CZU: 616.33-008.1-031-08 | ||||||
Pag. 33-35 | ||||||
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Rezumat | ||||||
Research is focused on the study of the polymorphism of NOS1 and NOS2 gene, encoding nitric oxide synthases, in patients with gastroesophageal reflux disease (GERD). The study was conducted on 106 patients with GERD and 106 healthy individuals (case-control). It was found that carriers of genotype T/T C/T of the gene NOS1 in patients with GERD and duration of disease more than 10 years have an association with an increased risk of development of erosive esophagitis 3 times greater than C/C and C/T. According to available data, we find that genotype C/C of the gene NOS1 manifest a protective function in the development of severe gastroesophageal reflux disease. Allelic variant C/C of NOS2 gene is more common in patients with GERD, compared with controls. Carriers genotype C/C polymorphism of the gene G954C NOS2 in patients with GERD and duration of the disease more than 10 years have an association with an increased risk for the development of erosive esophagitis 3,9 times greater than the G/G and G/C . |
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Cuvinte-cheie gastroesophageal reflux disease, polymorphism |
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Cerif XML Export
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The study was conducted on 106 patients with GERD and 106 healthy individuals (case-control). It was found that carriers of genotype T/T C/T of the gene NOS1 in patients with GERD and duration of disease more than 10 years have an association with an increased risk of development of erosive esophagitis 3 times greater than C/C and C/T. According to available data, we find that genotype C/C of the gene NOS1 manifest a protective function in the development of severe gastroesophageal reflux disease. Allelic variant C/C of NOS2 gene is more common in patients with GERD, compared with controls. Carriers genotype C/C polymorphism of the gene G954C NOS2 in patients with GERD and duration of the disease more than 10 years have an association with an increased risk for the development of erosive esophagitis 3,9 times greater than the G/G and G/C . </cfAbstr> <cfAbstr cfLangCode='RU' cfTrans='o'>Исследование было посвящено изучению полиморфизма генов, кодирующих синтаз оксид азота, NOS1 и NOS2 у больных с гастроэзофагеальной рефлюксной болезни (ГЭРБ). Исследование было проведено у 106 пациентов с ГЭРБ и 106 здоровых людей. Было обнаружено, что носители генотипа T/T полиморфизма C/T гены NOS1 у пациентов с ГЭРБ с длительностью заболевания более 10 лет имеют риск развития эрозивного эзофагита в 3 раза выше, чем у носителей генотипа C/C и C/T. Наши результаты показывают, что генотип C/C гены NOS1 проявляет защитную функцию в развитии тяжелых форм гастроэзофагеальной рефлюксной болезни. 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