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SCURTU, Alina; ISTRATI, Valeriu; SCORPAN, Anatolie; GAVRILIUC, Svetlana. Rolul polimorfismului genelor sintazelor oxidului nitric in boala de reflux gastroesofagian. In: Arta Medica . 2016, nr. 2(59), pp. 33-35. ISSN 1810-1852.
|Numărul 2(59) / 2016 / ISSN 1810-1852|
Research is focused on the study of the polymorphism of NOS1 and NOS2 gene, encoding nitric oxide synthases, in patients with gastroesophageal reflux disease (GERD). The study was conducted on 106 patients with GERD and 106 healthy individuals (case-control). It was found that carriers of genotype T/T C/T of the gene NOS1 in patients with GERD and duration of disease more than 10 years have an association with an increased risk of development of erosive esophagitis 3 times greater than C/C and C/T. According to available data, we find that genotype C/C of the gene NOS1 manifest a protective function in the development of severe gastroesophageal reflux disease. Allelic variant C/C of NOS2 gene is more common in patients with GERD, compared with controls. Carriers genotype C/C polymorphism of the gene G954C NOS2 in patients with GERD and duration of the disease more than 10 years have an association with an increased risk for the development of erosive esophagitis 3,9 times greater than the G/G and G/C .
gastroesophageal reflux disease, polymorphism