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Articolul urmator |
808 9 |
Ultima descărcare din IBN: 2024-01-27 13:32 |
Căutarea după subiecte similare conform CZU |
618.14-002:618.7-007.16]-084 (1) |
Științe medicale. Medicină (10970) |
SM ISO690:2012 CURTEANU, Ala, CARAUŞ, Tamara. Rolul infecţiei materno-fetale în morbiditatea, mortalitatea şi dizabilitatea copiilor premature. In: Buletin de Perinatologie, 2016, nr. 1(69), pp. 5-14. ISSN 1810-5289. |
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Buletin de Perinatologie | |||||||
Numărul 1(69) / 2016 / ISSN 1810-5289 | |||||||
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CZU: 618.14-002:618.7-007.16]-084 | |||||||
Pag. 5-14 | |||||||
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The purpose of the study was to determine the incidence, structure, risk factors for MFI developing in premature newborns, bacteriological profi le, effi cacy of diagnostic tests and treatment of this nosology, as well as to determine neurologic sequelae at 2 years age. Material and methods. A prospective cohort study that included 200 premature babies born at MCI was conducted in 2011-2014. Division of babies per groups was performed according to their weight at birth: group I - 86 babies with birth weight ≤1499g (VLBW) and group II - 114 children weighing intermediate (IW) ≥1500g. Besides anamnestic and clinical parameters, laboratory indices were studied to confi rm the MFI (blood formula and indices calculated on its basis, C-reactive protein, acid-base balance, procalcitonin and interleukin 6 (IL-6), instrumental investigations and blood culture). Neurological development was assessed in 109 (54,5%) babies. Results. The overall MFI incidence was 68,0 ‰ and death rate – 170,0‰, with higher rates in VLBW babies – 89,5‰ and 209,3‰, respectively. Among the risk factors commonly associated with MFI are the following: maternal infectious pathology (52,0%), PRM (67,5%), chorioamnionitis (10,0%) and hyperthermia in birth (6,5%). Gram-positive fl ora prevails in microbiological profi le (74,2%). The absolute number of neutrophils and the immature/total ratio showed positive values in 1/3 cases, and the most sensitive pro-infl ammatory marker was shown to be IL-6. The fi rstline antibacterial therapy has corresponded to the standards of good practices. Conclusions. VLBW newborns have higher risks of developing MFI, whose correct management is based on anamnestic, clinical and laboratory risk factors, determined in the study, as well as on severe neurological sequelae. |
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