In this research, medicinal and aromatic species of Lamiaceae family, spontaneously growing in local flora, were detected. In the flora of the Republic of Moldova, Lamiaceae family is represented by 28 genera and 82 species. Out of a total number of native Lamiaceae species, 57 have been documented for medicinal use. But much less of them are actually used in both official and folk medicine in our country. Thirteen genera, including therapeutically important species, are widely represented and distributed in all parts of the country. More than twenty species with high frequency and abundance can be recommended to be harvested and valorized without damaging their natural populations.