Background: Medical rehabilitation of persons who have undergone unilateral transtibial amputees is a complex and multildimensional process. The presence of comorbidities and their complications increase mortality levels and slow down the process of rehabilitation. Material and methods: 472 medical records of patients admitted during the years 2015 to 2016 were analyzed. 142 patients were selected because of unilateral transtibial amputations of diabetic complications with analysis of clinical diagnosis and concomitant pathologies. By examining clinical and functional, were evaluated dolor syndrome and goniometric knee joint of the amputated side. All patients received medical rehabilitation and orthopedic care in the hospital. Clinical and functional status was assessed in dynamics after treatment, and at 6 months. Results: of somatic pathologies, cardiovascular diseases (hypertension – 88%, ischemic heart disease – 54%) are first mentioned in the concomitant diagnosis on admission, the most frequent pathologies associated with diabetes and in recitals average age of the study group. Dolor syndrome and functional status during rehabilitation treatment, improved significantly from 7.9 0.16 points, to 4.1 0.03 points, and knee extension deficit decreased on average by 4.69 degrees. After discharge home both indices did not support essential amendments. Conclusions: To streamline the process of medical rehabilitation and improvement of the prosthetics of patients with amputations of lower limbs should be considered concomitant pathologies present and their long-term monitoring.