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SM ISO690:2012 GHELIMICI, Tatiana, LUPAŞCO, Iulianna, DUMBRAVA, Vlada-Tatiana. Leziunile gastroduodenale cauzate de Helicobacter pylori in hepatita cronică virală B. In: Curierul Medical, 2010, nr. 6(318), pp. 28-30. ISSN 1875-0666. |
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Curierul Medical | |||||||
Numărul 6(318) / 2010 / ISSN 1875-0666 | |||||||
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Pag. 28-30 | |||||||
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Chronic Hepatitis B and Gastro-Duodenal Lesions Caused by Helicobacter Pylori Infection The study involved 58 patients with Chronic Hepatitis B (CHB), which were dominated by males - 62.07% (36) and persons younger than 45 years, 65.52% (38). All patients underwent clinical, laboratory and instrumental examination of the functional state of the liver, FGDS, and determined the presence of HP in gastric mucosa. Histological and urease methods assessed the degree of colonization of HP in the gastric mucosa from minimum: ( ) - gr. A, up to maximum: ( ) - gr. B. In CHB severity of bacterial infection of the gastric mucosa caused by HP occurs more frequently in men and in patients younger than 45 years, with a maximum degree of activity of hepatic process. The degree of HP infection of the gastric mucosa influences clinical course of disease in CHB. The symptoms of heartburn, vomiting, epigastric pain observed in 100% of cases in a maximum degree of colonisation of HP (gr. B). At the same time the asthenic syndrome, 95.35% (41) and hepatomegaly, 90% (45), chronic gastritis -77.5%, chronic duodenitis-88, 8% were observed more often. The erosive forms of gastro-duodenal alterations predominated in the group with a significant degree of HP contamination in gastric mucosa. The CHB, gr. B patients, demonstrated significant increase in the activity of AST, increase of Ig A, CIC concentration, and total T-lymphocytes with reduction of B-lymphocytes. The above mentioned data indicate a relationship between the two infections: bacterial-HP and viral-VHB. Persistence of HP infection aggravates immune abnormalities in patients with CHB and promotes the progression of hepatic process. |
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Cuvinte-cheie chronic hepatitis B, Helicobacter pylori |
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