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618.2-06-036:616.379-008.64 (2) |
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SM ISO690:2012 ALEXA, Zinaida, CASIEANCIUC, Anastasia, HAREA, Dumitru. Evoluţia naturală a diabetului gestaţional. In: Buletin de Perinatologie, 2015, nr. 2(66), pp. 70-73. ISSN 1810-5289. |
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Buletin de Perinatologie | ||||||
Numărul 2(66) / 2015 / ISSN 1810-5289 | ||||||
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CZU: 618.2-06-036:616.379-008.64 | ||||||
Pag. 70-73 | ||||||
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Gestational diabetes is the most common metabolic disorder of pregnancy, complicating 1-3% of all pregnancies. Women diagnosed with gestational diabetes are at increased risk for diabetes later in life with world wide reported incidence rate ranging widely from 6 to 62%. Most women with gestational diabetes who develop diabetes after pregnancy will develop type 2 diabetes, but the diagnosis of gestational diabetes may also identify women at increased risk for type 1 diabetes. Autoantibodies to pancreatic β-cell antigen precede the clinical onset of type 1 diabetes, which represents the endpoint of a chronic immune-mediated destruction of insulin producing β-cells. In first-degree relatives, the presence of two or more autoantibodies (ICA, GAD, IA2) is highly predictive for the development of type 1 diabetes. An increased body mass index before pregnancy, age over 40 years and an increased level of C-peptid can be predictors of diabetes mellitus type 2 after gestational diabetes. Hyperglycaemia diagnosed during pregnancy can have the following postpartum evolution: normalization of blood sugar, preservation of hyperglycaemia and development of diabetes mellitus or can be a predictor for the endpoint of a chronic immune-mediated destruction of insulin producing β-cells. However, information concerning the prevalence and predictive value of this factors in women with gestational diabetes is scarce. Here we describe four cases of diabetes mellitus complicating pregnancy, with different evolution after delivery. |
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Cuvinte-cheie gestational diabetes, diabetes mellitus, antibodies, ICA, GAD |
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