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Articolul urmator |
836 4 |
Ultima descărcare din IBN: 2024-02-26 18:16 |
Căutarea după subiecte similare conform CZU |
618.11-07-083/.085 (1) |
Științe medicale. Medicină (11142) |
SM ISO690:2012 SÂRBU, Zinaida. Insuficienţa ovariană prematura: controverse în tratament. In: Buletin de Perinatologie, 2015, nr. 1(65), pp. 40-45. ISSN 1810-5289. |
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Buletin de Perinatologie | ||||||
Numărul 1(65) / 2015 / ISSN 1810-5289 | ||||||
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CZU: 618.11-07-083/.085 | ||||||
Pag. 40-45 | ||||||
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Rezumat | ||||||
Background: In our country the age at which menopause starts is 49-55 years old in average. Premature ovarian failure (POF) is a clinical syndrome, with typical sign, like episodic or stabile amenorrhoea in women younger than 40 y.o. The goal of the study was to develop proper management for POF patients. Methods: 91 women with POF were included in the study. A special questionnaire was designed and used for the collection of the individual medical history details. The record included: age at fi rst visit; live anamnesis, somatic and gynaecological anamnesis, weight and body mass index; presence/absence of feature of the metabolic syndrome (MS) according to World Health Organization (WHO) criteria; Kupperman index. All patients have been evaluated using physical data, as well as instrumental examination - ultrasound examination; histological investigation; roentghenography of „seli turcica”; mamography and hormonal profi les, including serum concentrations of LH; FSH; E2, T, Prl,TSH. The obtained data has been assessed through descriptive statistics method, with average and standard deviation and confi dence interval 95%. Rezults: The particularities of the POF treatment differed, depending on the age at which POF appeared. If it happened at the reproductive age, than HRT was preferential, with dosage corresponding to the early follicular phase Estradiol valerate – 2 mg progestins. The OC for this group was not most appropriate. After 5 years of HRT treatment the switch was considered, taking into account clinical and hormonal status. One option was HRT medication with Estradiol Vaelrate 1 mg progesterone 10 mg. After reaching the age of the physiological menopause (52-54 y.o in Moldova) the treatment was done with HRT medication with Estradiolvalerate 1 mg progesterone 5 mg. The selected progestin depended on the hormonal status and phenotype of the woman. The clinical symptoms of the menopause have disappeared after 3 months of HRT treatment. During following 11 years of treatment there was no case reported on osteoporosis, coronary heart disease, depression, and other late POF symptoms. While in the group of patients, who did not follow HRT treatment ( 8 women had diet with very high input of soy products) the POF symptoms persisted, and in few years late and severe menopausal symptoms have appeared. Conclusions: The results of our study proved that in time initiation of the treatment with properly selected HRT in women with POF improve their quality of life. These patients are to be in the gynaecologist-endocrinologist supervision and monitoring. The specialist requires enough knowledge and also psychological counselling abilities. |
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Cuvinte-cheie POF, RHT, COC, T |
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