A fost efectuată analiza indicilor metabolismului azotat (IMA), in special ai aminoacizilor liberi (AAL), la copii cu epilepsie. Analiza materialului a fost realizată prin metoda cromatografiei lichide la analizorul de aminoacizi AAA 339 M. Datele au demonstrat o stare de hipoaminoacidemie pronunţată, cea mai redusă fiind concentraţia aspartatului, treoninei, asparaginei, glutamatului, glutaminei, fenilalaninei, triptofanului, lizinei, argininei şi a histidinei. Creşterea nivelului sumar al aminoacizilor cu conţinut de sulf a fost insoţită de un dezechilibru al concentraţiilor lor individuale, printr-un nivel crescut de acid cisteic şi al cisteinei, şi redus al metioninei şi al taurinei. A fost depistată şi o creştere constantă a conţinutului de etanolamină şi de amoniac liber in sange, dar şi o reducere a aminoacizilor liberi: esenţiali, neesenţiali, imunoactivi şi cetogeni. A fost studiat profilul aminoacizilor in serul sanguin şi urină ca indicatori ai metabolismului azotat la copiii diagnosticaţi cu epilepsie. Datele au demonstrat că in perioada de remisiune se observă creşterea nivelului de AAL de inhibiţie, sporirea indicelui AAL de inhibiţie/excitaţie și scăderea indicelui serină/etanolamină. Cel mai semnificativ s-au redus indicii glutamină/ amoniac şi uree/amoniac. Profilul de aminoacizi a fost insoţit de un dezechilibru pronunţat al aminoacizilor cu conţinut de sulf şi de scăderea indicelui aminoacizilor esenţiali/neesenţiali, ceea ce permite utilizarea lor in calitate de marker nespecific al nivelului de sănătate.

There was performed the analysis of nitrogen metabolism indices (MI), particularly of free amino acids (ALA) in children with epilepsy. Analysis of the material was performed by liquid chromatography with Amino Acid Analyzer AAA 339 M. The data showed a marked hypoaminoacidemia state, the lowest being the concentration of aspartate, threonine, asparagine, glutamate, glutamine, phenylalanine, tryptophan, lysine, arginine and histidine. Increased summary level of sulphur-containing amino acids was accompanied by an imbalance of their individual concentrations, through high levels of cysteic acid and cysteine, and reduced methionine and taurine. It was found an increase of ethanolamine and free ammonia content in the blood, and a reduction of some free amino acids: essential, nonessential, immunoactive and ketogenic. It was researched the amino acid profile in serum and urine, as indicators of nitrogen metabolism, in children with epilepsy. The data showed that during remission there was observed an increase of inhibition ALA, increase of ALA inhibition/excitation index and decrease of serine/ethanolamine index. Most significantly were decreased glutamine/ammonia and urea/ammonia indexes. Amino acid profile was accompanied by a marked imbalance of sulphur-containing amino acids and a decrease of essential/nonessential amino acid index that allows their usage as a nonspecific marker of the health level.