|Conţinutul numărului revistei|
|Ultima descărcare din IBN:|
| SM ISO690:2012|
GRAUR, Vasilii О.; ZARICIUC, Elena; TSAPKOV, Victor I.; BARBA, Nina; GULEA, Aurelian. Synthesis and biological activity of nickel and copper coordination compounds of 5-nitrofuran-2-carbaldehyde N(4)-allyl-3-thiosemicarbazone. In: Studia Universitatis Moldaviae (Seria Ştiinţe Reale şi ale Naturii). 2014, nr. 6(76), pp. 119-123. ISSN 1814-3237.
|Studia Universitatis Moldaviae (Seria Ştiinţe Reale şi ale Naturii)|
|Numărul 6(76) / 2014 / ISSN 1814-3237 /ISSNe 1857-498X|
The paper presents the synthesis of the ligand 5-nitrofuran-2-carbaldehyde N(4)-allyl-3-thiosemicarbazone (HL) and eight coordination compounds of copper(II) and nickel(II) with this ligand. The structure of thiosemicarbazone HL was studied using 1H and 13С NMR spectroscopy. For the synthesized compounds their antimicrobial and antifungal activity was studied on a series of standard strains. For HL and Cu(HL)2(NO3)2 the antitumor activity towards human leukemia HL-60 cells was estimated. It was established that coordination compounds manifest better activity than free ligand.
5-nitrofuran-2-carbaldehyde, biological activity.