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575.1:616.12(478) (1) |
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SM ISO690:2012 CAPROŞ, Natalia, BARBACAR, Nicolae, ISTRATI, Valeriu, POPESCU, Victor, BUTOVSCAIA, Cristina. Genetic factors that predispose to coronary artery disease.. In: Buletinul Academiei de Ştiinţe a Moldovei. Ştiinţele vieţii, 2015, nr. 2(326), pp. 26-29. ISSN 1857-064X. |
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Buletinul Academiei de Ştiinţe a Moldovei. Ştiinţele vieţii | |
Numărul 2(326) / 2015 / ISSN 1857-064X | |
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CZU: 575.1:616.12(478) | |
Pag. 26-29 | |
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Rezumat | |
The aim of the study was to evaluate the genetic factors that cause or predispose to coronary artery disease (CAD). The case control study was conducted in 2007-2011 and included 405 patients with coronary artery disease and acute ischemic episodes admitted to the Municipal Clinical Hospital „Sfânta Treime“, Chisinău. Insertion/deletion (I/D) genotypes of angiotensin-converting enzyme (ACE) and A1166C polymorphism of angiotensin II type 1 receptor gene, Asp298Glu (A/G) genotypes of the endothelial nitric oxide synthase (eNOS) and PlA1/2 (A1A2) genotypes of GPIIb/IIIa receptor polymorphisms were identified by amplified polymerase chain reaction and restricted fragment length polymorphism. The authors concluded that the carrier of D/D genotype and D allele in ACE gene, being positively correlated with the risk C/C polymorphic variant of angiotensin II type 1 receptor gene was associated with hypertension and cardiovascular death. A2/A2 genotype of glycoprotein (GP) IIb/IIIa receptor gene was associated with susceptibility to CAD and high frequency of myocardial infarction and dyslipidemia, particularly in smokers. 7 references. |
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Cuvinte-cheie coronary artery, genetic diagnosis, genetic factors. |
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