Studiul ReEs şi RePg în ţesutul tumoral la 140 paciente cu CGM, din care 41 cu cancer primar multiplu metacron al glandelor mamare (CPMMGM), a stabilit o frecvenţă înaltă a tumorilor ReEs şi RePs negative, ce reprezintă o particularitate a bolnavelor de CGM din Republica Moldova. Tumori ReEs şi RePg la vârsta menopauzală sunt prezente, practic, la fiecare a doua pacientă, ceea ce limitează posibilitatea tratamentului cu antiestrogeni şi progestine. Posibil că majorarea tumorilor ReEs şi RePg pozitive în cancerele metacrone este rezultatul tratamentului cimioterapic şi hormonal al primului cancer.

The study of ReEs and RePg in the tumor tissue of 140 patients with breast cancer, among which 41 patients with primary multiple metacron breast cancer, had established a high frequency of tumors with ReEs and RePg negative, that is characteristic for the patients with breast cancer in the Republic of Moldova. During the menopause the tumors ReEs and RePg negative are present practically at each second patient, which limits the possibility of treatment with ant estrogens and progestines. The majority of tumors ReEs and RePg positive in metacron cancer is possible the result of chemotherapy and hormonotherapy treatment of the fi rst breast cancer.