După cum au demonstrat rezultatele cercetărilor clinico-genetice efectuate, cancerul colorectal este o patologie multilaterală, la dezvoltarea căreia contribuie esenţial factorii genetici. A fost evi-denţiat caracterul comun al cancerului intestinului gros şi al adenocarcinoamelor. De asemenea, s-au formulat şi argumentat caracteristicile imunogenetice şi imunologice ale cadrului de premorbiditate la familiile cu risc sporit de cancer, indicat marcherii prognosticării nefavorabile la bolnavii cu can-cer intestinal şi riscul progresării neoplasmelor maligne primare multiple (NMPM). Este specificată corelaţia dintre rezultatele de tip imunologic şi cursul clinic al procesului patologic.

The results of clinical and morphological researches showed that the colorectal cancer is a multi-factorial pathology, in whose development great contributions have the genetical factors. The pathogenetical common character between adenomas and large intestine cancer was exposed.The immunogenetical and immunological characteristics of pre morbidity framework in families with high cancer risk were formulated and motivated; markers of unfavorable prognosis of patients with large intestine cancer and with risk of malign neoplasm primary multiple (MNPM) development were formulated as well. There is specifi ed the correlation between immunological results and the clinical course of the pathological process.The obtained data may be used as one of the pathogenetical requests for the person’s clinicalgenetical monitoring development, having a high risk of malign neoplasm advancement (including primary multiple) from genetical point of view