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SM ISO690:2012 COJOCARU, Victor, HOTINEANU, Vladimir, BORŞ, Mihai, CAZACOV, Vladimir, FERDOHLEB, Alexandru. Sindromul hepato-renal. In: Arta Medica , 2011, nr. 1(44), pp. 39-45. ISSN 1810-1852. |
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Arta Medica | ||||||
Numărul 1(44) / 2011 / ISSN 1810-1852 /ISSNe 1810-1879 | ||||||
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Pag. 39-45 | ||||||
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Hepatorenal syndrome (HRS) is a common complication of advanced cirrhosis, characterised by renal failure and major disturbances in
circulatory function. Renal failure is caused by intense vasoconstriction of the renal circulation. The diagnosis of HRS is currently based on the exclusion of other causes of renal failure. The prognosis is very poor, particularly when there is rapidly progressive renal failure (type 1). Liver transplantation is the best option in patients without contraindications to the procedure, but it is not always possible owing to the short survival expectancy. Therapies introduced during the past few years, such as vasoconstrictor drugs (vasopressin analogues, α-adrenergic agonists) or the transjugular intrahepatic portosystemic shunt, are effective in improving renal function. Nevertheless, liver transplantation should still be done in suitable patients even after improvement of renal function because the outcome of HRS is poor. |
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