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Ultima descărcare din IBN: 2020-02-12 14:39 |
SM ISO690:2012 SAENCO, A., ZAICICO, N., СТЕПАНЮК, Г.. Влияние натриевой соли 3-(2-оксо-3-фенил-2Н-[1,2,4]триазина[2,3-с] хиназолин-6-ил)
пропановой кислоты и бемитила на биохимические процессы в организме крыс в условиях ежедневных тренировок в третбане. In: Curierul Medical, 2014, nr. 6(57), pp. 31-36. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 6(57) / 2014 / ISSN 1875-0666 | ||||||
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Pag. 31-36 | ||||||
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Background: The limited arsenal of actoprotectors by almost one bemethyl has caused the necessity to search the substances with the above action, suitable for the creation of a new drug on their basis.
Material and methods: For the investigation the substances of sodium salt of 3-(2-oxo-3-phenyl-2H-[1,2,4]triazine[2,3-c]quinazolin-6-yl) propane acid with the laboratory ciphers MT-279 has been taken. The studies have been performed on 56 nonlinear male rats in the conditions of the 15-daily physical loading which promoted the normalization of energy processes in skeletal muscles (energy resources were increased, lactoacidosis was removed, the lipolysis was activated) and interaction within system «pro-and antioxidant».
Results: It has been established that the course (15 days) intraperitoneal injections in rats with sodium salt of 3-(2-oxo-3-phenyl-2H-[1,2,4] triazine[2,3-c]quinazolin-6-yl) propane acid (MT-279, 2.5 mg/kg), as well as bemethyl (33 mg/kg) promoted the normalization of energy processes in skeletal muscles (energy resources were increased, lactoacidosis was removed, the lipolysis was activated) and interaction within system «pro-and antioxidant».
Conclusions: The compound MT-279 has the largest actoprotective effect virtually mapped to bemethyl. A complex of effects inherent of MT-279 compound indicates the advisability of the in-depth study of its pharmacological properties to find out its safety and suitability for creating a new drug on its basis. |
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Cuvinte-cheie propanoic acid, actoprotective action, MT-279, bemethyl, metabolic processes. |
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