Stress is a response to an event or condition in which there is a demand higher than normal amount of resolution. Stress is when you feel overwhelmed or threatened by many more requirements than you can handle. It affects the way people think, act and feel. Most vulnerable to factors stresogens are children. Their exposure to stressors strong and lasting shall open a chain of changes in the central nervous system and endocrine, through the hypothalamus- pituitary adrenocortical axis, with the release of stress hormones and immune system involvement. The purpose of this paper is the research content of cortisol in saliva, reflecting the stress response of the body to students involved in the educational process.