The tromboembolic syndrom in infective endocarditis Infective endocarditis is infection of the endocardium with bacteria or fungi. Endocarditis usually involves the heart valves. Major predisposing factors are congenital heart defects, rheumatic valvular disease, bicuspid or calcific aortic valves, mitral valve prolapse, and hypertrophic cardiomyopathy.Vegetative cardiac lesion is the main manifestation of infective endocarditis which can lead to structural modifications in the heart and systemic embolism. The incidence of infective endocarditis in the world turns out to be 1, 9-6, 2% and mortality consists 20-25%. Systemic embolism is the most common and prognostic ally relevant complication of infective endocarditis, observed in 22–43% of cases, with a higher prevalence of cerebral that peripheral/visceral manifestations. Systemic consequences are primarily due to embolization of infected material from the heart valve. Right-sided lesions typically produce septic pulmonary emboli, which may result in pulmonary infarction, pneumonia, or empyema. Left-sided lesions may embolize to any tissue, particularly the kidneys, spleen. It was ascertained that the biggest part of embolic complications in infective endocarditis had been caused by Staphylococcus aureus, Candida, and other microorganisms from HACEK group. It was found out that embolic complications registered in infective endocarditis had been determined at the patients with huge and mobile vegetations localized on the mitral valve followed by the aorta valve. The authors present you a case about a patient with infective endocarditis, systemic embolism with involving in to the process of 3 arteries (retinal, cerebral, renal) and anti-cardiolipin antibodies (ACL).