Tuberculosis is a multi-pathogenetic disease, its treatment response is influenced by the degree immune disturbances. An acute progressive evolution with extensive destruction and dissemination provokes the lowest treatment results, which in most cases are influenced by a heterogeneous immune response. The immunological data obtained before and after the treatment of 54 new pulmonary TB cases have been compared with the data of 50 healthy individuals. By a blind selection 27 TB patients have been included in the control study group and have been treated with the standard antituberculosis treatment and immunocorrecting medicine BioR. The immune indices of 27 cases treated only with standard antituberculosis treatment have been compared with the control group. The associated antituberculosis treatment have reduced the severity of the immune defficiency, reduced the increased immune globulin level, increased the organism’s sensibilisation to bacteriological and micobacteriological antigens, reduced the intoxication indices. Despite the immuno-regulatory activity of the medicine BioR, the comprehensive TB treatment in general has not improved the treatment results, as one course of treatment is insufficient for a complete immune rehabilitation and the involvement of other factors, influencing the treatment outcomes is required.