Date privind inofensivitatea imunizărilor incluse în Programul Naţional de Imunizări în Republica Moldova
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2020-03-24 17:58
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BUCOV, Victoria, ŢURCAN, Laura, MELNIC, Anatolie, FURTUNA, Nicolae. Date privind inofensivitatea imunizărilor incluse în Programul Naţional de Imunizări în Republica Moldova. In: Curierul Medical, 2013, nr. 6(56), pp. 83-86. ISSN 1875-0666.
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Curierul Medical
Numărul 6(56) / 2013 / ISSN 1875-0666

Date privind inofensivitatea imunizărilor incluse în Programul Naţional de Imunizări în Republica Moldova

Pag. 83-86

Bucov Victoria, Ţurcan Laura, Melnic Anatolie, Furtuna Nicolae
 
Centrul Naţional de Sanătate Publică
 
Disponibil în IBN: 12 martie 2014


Rezumat

The purpose of this article is epidemiological analysis of adverse events following immunization (AEFI) registered in the Republic of Moldova in 2007-2012 on the basis of registration forms. In total there were 534 AEFI, mostly reactions after BCG (409-76.6 ± 3.7%) compared to the DTP, Penta (104-19.5 ± 3.4%) and MMR (21-3.9 ± 1.7%). AEFI after the introduction of hepatitis B vaccine, OPV and Td for adults and adolescents have not been registered. After BCG most AEFI are lymphadenitis, 82.4 ± 3.8%, often in the first two months after vaccination, significantly higher after the first dose compared to the second. Other reactions were cold abscesses – 8.3 ± 2.7%, ulceration – 6.1 ± 2.4%, scars – 1.7 ± 1.2% and osteitis – 1.5 ± 1.2%, occurring more often after the second dose of vacсine. It should be stated improper introduction of BCG. The vast majority of AEFI after the DPT and the pentavalent vaccine are systemic reactions, 90.7 ± 5.6% compared to local, 9.3 ± 5.6%, p < 0001, and it is possible to state the underdiagnosis of local AEFI. The greatest number of AEFI after DTP and pentavalent vaccine occur within the first 1-10 hours, 78.5 ± 8.1%, often within 1-6 hours, 49.6 ± 9.8%. Thus, more active monitoring of vaccinated children should be carried out during this period of time. Surveillance system for AEFI requires standardization in reporting and harmonization of registration forms.

Cuvinte-cheie
immunization,

adverse events following immunization.