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SM ISO690:2012 BUCOV, Victoria, ŢURCAN, Laura, MELNIC, Anatolie, FURTUNA, Nicolae. Date privind inofensivitatea imunizărilor incluse în Programul Naţional de Imunizări în Republica Moldova. In: Curierul Medical, 2013, nr. 6(56), pp. 83-86. ISSN 1875-0666. |
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Curierul Medical | |||||
Numărul 6(56) / 2013 / ISSN 1875-0666 | |||||
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Pag. 83-86 | |||||
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The purpose of this article is epidemiological analysis of adverse events following immunization (AEFI) registered in the Republic of Moldova in 2007-2012 on the basis of registration forms. In total there were 534 AEFI, mostly reactions after BCG (409-76.6 ± 3.7%) compared to the DTP, Penta (104-19.5 ± 3.4%) and MMR (21-3.9 ± 1.7%). AEFI after the introduction of hepatitis B vaccine, OPV and Td for adults and adolescents have not been registered. After BCG most AEFI are lymphadenitis, 82.4 ± 3.8%, often in the first two months after vaccination, significantly higher after the first dose
compared to the second. Other reactions were cold abscesses – 8.3 ± 2.7%, ulceration – 6.1 ± 2.4%, scars – 1.7 ± 1.2% and osteitis – 1.5 ± 1.2%, occurring more often after the second dose of vacсine. It should be stated improper introduction of BCG. The vast majority of AEFI after the DPT and the pentavalent vaccine are systemic reactions, 90.7 ± 5.6% compared to local, 9.3 ± 5.6%, p < 0001, and it is possible to state the underdiagnosis of local AEFI. The
greatest number of AEFI after DTP and pentavalent vaccine occur within the first 1-10 hours, 78.5 ± 8.1%, often within 1-6 hours, 49.6 ± 9.8%. Thus, more active monitoring of vaccinated children should be carried out during this period of time. Surveillance system for AEFI requires standardization in reporting and harmonization of registration forms. |
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Cuvinte-cheie immunization, adverse events following immunization. |
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