The aim of the research is to study the therapeutic action of the new combined dental gel Rotrin-Denta on the dynamics of the inflammatory process in the mucous membrane of the mouth and hematological indexes of rats in the conditions of experimental gingivitis. The model pathology has been produced in two stages. Firstly dysbiosis of the mouth cavity has been modeled by means of intragastric injection of the liquid antibiotic lincomycin during five days. After that the local gums defeat of the rats has been caused by using a dispersion of bee venom during six days. The studied gel and the comparison preparation – gel Kamident-Health – have been applied on the gingival disease areas of a lower jaw bone twice a day during nine days starting with the 14th day of the experiment. The intensity of the development of the inflammatory process and the efficiency of the treatment have been evaluated by the degree of the inflammatory process of the mucous membrane of the atrium of mouth cavity and cheek in grades and on the ground of the results of hematological researches (amount of leucocytes, sedimentation rate of erythrocytes, leukogram) in dynamics on the 11th, 13th, 18th and 22nd day. The research has established an anti-inflammatory action of the gel Rotrin-Denta on the mucous membrane of the mouth, what has been testified by the decrease of the local clinical signs of the pathological process and the positive influence on the dynamics of the blood indexes which was more significant on the 9th day of the treatment. The tunica mucosa of the vestibule and cheek of rats has been regenerated. The local effect of inflammation has been decreased along with the improvement of blood indexes: the amount of leucocytes and sedimentation rate of erythrocytes have been decreased (by 1.7 and 2.3 times correspondingly) in comparison with the indexes of the animals from the group of positive control, and the recovery up to the indexes of the animals from the group of intact control has taken place. The normalization of the amount of lymphocytes and segmented neutrophils has been shown in the leukogram. The therapeutic action of the new combined dental gel Rotrin-Denta exceeds the efficiency of the reference preparation gel Kamident-Health.