Modifications in the technology of foodstuff producing, storage and realization, the change of eating behavior along with the endless globalization process are followed by the intensive growth of salmonellosis, thus the permanent epidemiologic monitoring of this group of infections is necessary. The manifestations of the epidemic process of salmonellosis have been studied by an epidemic retrospective analysis and a random retrospective survey of “case – control” type. This article illustrates the analyzed data from Kemerovo region: 41820 cases of salmonellosis disease (1992-2012 г.г.), 1759 cards of the epidemiological study from the disease center (2011-2012 г.г.), the results of bacteriological monitoring (94790 samples of materials of animal origin and objects of the environment). Two periods of salmonellosis morbidity have been identified, which had significant differences in the intensity of epidemic process (the first one – from 1995 to 2004, the second one – from 2005 to 2012). During the first period the morbidity sharply decreased (Тпр. = 9.24%), in the second period, on the contrary, it raised (Тпр. = 9.60%). The growth of the number of the disease cases provoked by salmonella of serogroup D (Salmonella enteritidis) has been discovered. The maximum rate of the salmonellosis morbidity in the annual dynamics has been detected in August, the minimum one – in December. The special group of high risk is babies from 0 to 2 years old. It has been discovered that the majority of morbidities have been caused by a nutritional factor. There is a high rate of correlation between salmonella diseases and eating eggs and poultry products (OR = 4.27). It is obvious that the preventive measures for salmonellosis should be improved.